Simone Michelan-Duarte
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Explore the profile of Simone Michelan-Duarte including associated specialties, affiliations and a list of published articles.
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10
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12
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Recent Articles
1.
da Silva Oliveira D, Sousa Silva N, Jacques Dit Lapierre T, de Souza S, Ferreira Brito N, Cassiano Martinho A, et al.
Chem Biodivers
. 2024 Sep;
22(2):e202402100.
PMID: 39327235
Microorganisms can induce diseases with significant clinical implications for human health. Multidrug-resistant microorganisms have been on the rise worldwide over the past few decades, and no new antibiotics have been...
2.
Espinoza-Chavez R, de Oliveira Rezende Junior C, De Souza M, Consolin Chelucci R, Michelan-Duarte S, Krogh R, et al.
ChemMedChem
. 2024 Jun;
19(20):e202400293.
PMID: 38924252
This study introduces further insights from the hit-to-lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the cruzain enzyme, which targets Trypanosoma cruzi, the causative parasite...
3.
Jacques Dit Lapierre T, Nascimento Farago D, Cruz M, Resende D, de Oliveira A, Dos Santos B, et al.
Chem Biol Drug Des
. 2024 Apr;
103(4):e14525.
PMID: 38627214
An early exploration of the benzothiazole class against two kinetoplastid parasites, Leishmania infantum and Trypanosoma cruzi, has been performed after the identification of a benzothiazole derivative as a suitable antileishmanial...
4.
Espinoza-Chavez R, de Oliveira Rezende Junior C, De Souza M, Pauli I, Valli M, Gomes Ferreira L, et al.
Future Med Chem
. 2024 Jan;
16(3):253-269.
PMID: 38193294
Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of paramount importance. Hit-to-lead exploration...
5.
de Oliveira Rezende Junior C, Martinez P, Ferreira R, Koovits P, Miranda Soares B, Ferreira L, et al.
Eur J Med Chem
. 2022 Dec;
246:114925.
PMID: 36459758
Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. Because current treatments present several limitations, including long duration, variable efficacy and serious side effects, there is an urgent...
6.
Pauli I, Rezende Jr C, Slafer B, Dessoy M, de Souza M, Ferreira L, et al.
Front Pharmacol
. 2022 Jan;
12:774069.
PMID: 35069198
Cruzain, the main cysteine protease of , plays key roles in all stages of the parasite's life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion...
7.
S de Oliveira A, S Mello L, H Ogihara C, Doring T, Palomino-Salcedo D, Michelan-Duarte S, et al.
Future Med Chem
. 2021 Oct;
13(24):2167-2183.
PMID: 34708659
Schiff bases are synthetically accessible compounds that have been used in medicinal chemistry. In this work, 27 Schiff bases derived from diaminomaleonitrile were synthesized in high yields (80-98%). Molecular docking...
8.
Koovits P, Dessoy M, Matheeussen A, Maes L, Caljon G, Ferreira L, et al.
RSC Med Chem
. 2021 Jun;
11(11):1267-1274.
PMID: 34085041
A series of benzene sulphonamides with good potency and selectivity against spp. intracellular amastigotes was identified by high-throughput screening. Approximately 200 compounds were synthesized as part of a hit-to-lead optimization...
9.
Ferreira R, de Oliveira Rezende Junior C, Martinez P, Koovits P, Miranda Soares B, Ferreira L, et al.
PLoS Negl Trop Dis
. 2021 Feb;
15(2):e0009196.
PMID: 33617566
Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks...
10.
Murakami M, Michelan-Duarte S, Cintra A, Arni R
Biochim Biophys Acta
. 2004 Dec;
1703(1):79-81.
PMID: 15588705
Snake venom PLA(2)s have been extensively studied due to their role in mediating and disrupting physiological processes such as coagulation, platelet aggregation and myotoxicity. The Ca(2+) ion bound to the...