Lucas Treps
Overview
Explore the profile of Lucas Treps including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
3257
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0
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Recent Articles
31.
Eelen G, de Zeeuw P, Treps L, Harjes U, Wong B, Carmeliet P
Physiol Rev
. 2017 Nov;
98(1):3-58.
PMID: 29167330
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases....
32.
Harford-Wright E, Andre-Gregoire G, Jacobs K, Treps L, Le Gonidec S, Leclair H, et al.
Brain
. 2017 Oct;
140(11):2939-2954.
PMID: 29053791
Glioblastoma are highly aggressive brain tumours that are associated with an extremely poor prognosis. Within these tumours exists a subpopulation of highly plastic self-renewing cancer cells that retain the ability...
33.
Treps L, Perret R, Edmond S, Ricard D, Gavard J
J Extracell Vesicles
. 2017 Aug;
6(1):1359479.
PMID: 28815003
Glioblastoma multiforme (GBM) are mortifying brain tumours that contain a subpopulation of tumour cells with stem-like properties, termed glioblastoma stem-like cells (GSCs). GSCs largely contribute to tumour initiation, propagation and...
34.
Wong B, Marsch E, Treps L, Baes M, Carmeliet P
EMBO J
. 2017 Jun;
36(15):2187-2203.
PMID: 28637793
In contrast to the general belief, endothelial cell (EC) metabolism has recently been identified as a driver rather than a bystander effect of angiogenesis in health and disease. Indeed, different...
35.
Bierhansl L, Conradi L, Treps L, Dewerchin M, Carmeliet P
Physiology (Bethesda)
. 2017 Feb;
32(2):126-140.
PMID: 28202623
The importance of endothelial cell (EC) metabolism and its regulatory role in the angiogenic behavior of ECs during vessel formation and in the function of different EC subtypes determined by...
36.
Cantelmo A, Conradi L, Brajic A, Goveia J, Kalucka J, Pircher A, et al.
Cancer Cell
. 2016 Nov;
30(6):968-985.
PMID: 27866851
Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyper-glycolytic...
37.
Treps L, Gavard J
Methods Mol Biol
. 2016 Oct;
1493:417-427.
PMID: 27787868
Blood vessels compartmentalize blood flow and irrigate tissues, while allowing bidirectional exchanges. Vascular permeability permits fluids, small molecules and cells to cross the endothelial barrier. This process can be modulated,...
38.
Leclair H, Andre-Gregoire G, Treps L, Azzi S, Bidere N, Gavard J
FEBS Lett
. 2016 Sep;
590(20):3660-3668.
PMID: 27616439
Cell-cell contacts coordinate the endothelial barrier function in response to external cues. To identify new mediators involved in cytokine-promoted endothelial permeability, we screened a siRNA library targeting E3 ubiquitin ligases....
39.
Pircher A, Treps L, Bodrug N, Carmeliet P
Atherosclerosis
. 2016 Sep;
253:247-257.
PMID: 27594537
Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite improved insight into disease pathogenesis and therapeutic options, additional treatment strategies are required. Emerging evidence highlights the...
40.
Treps L, Conradi L, Harjes U, Carmeliet P
Pharmacol Rev
. 2016 Jul;
68(3):872-87.
PMID: 27363442
Excessive angiogenesis (i.e., the formation of new blood vessels) contributes to different pathologies, among them cancer and ocular disorders. Conversely, dysfunction of endothelial cells (ECs) contributes to cardiovascular complications, as...