Mieke Dewerchin
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Explore the profile of Mieke Dewerchin including associated specialties, affiliations and a list of published articles.
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123
Citations
9792
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Recent Articles
1.
Grootaert M, Pasut A, Raman J, Simmonds S, Callewaert B, Col U, et al.
Cardiovasc Diabetol
. 2025 Feb;
24(1):62.
PMID: 39920783
Background: Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disease associated with metabolic comorbidities. Microvascular dysfunction has been proposed to drive HFpEF, likely via endothelial cell (EC)...
2.
Gunther D, Bergerbit C, Marsee A, Vedaraman S, Pueyo-Moliner A, Pueyo Moliner A, et al.
Biofabrication
. 2025 Jan;
17(2).
PMID: 39854847
Bioprinting is currently the most promising method to biofabricate complex tissueswith the potential to transform the future of organ transplantation and drug discovery. Efforts to create such tissues are, however,...
3.
Declercq M, Treps L, Geldhof V, Conchinha N, de Rooij L, Subramanian A, et al.
Liver Int
. 2024 Jun;
44(9):2382-2395.
PMID: 38847551
Background & Aims: Cystic fibrosis (CF) is considered a multisystemic disorder in which CF-associated liver disease (CFLD) is the third most common cause of mortality. Currently, no effective treatment is...
4.
de Zeeuw P, Treps L, Garcia-Caballero M, Harjes U, Kalucka J, De Legher C, et al.
Commun Biol
. 2024 May;
7(1):618.
PMID: 38783087
Endothelial cells (ECs) are highly glycolytic, but whether they generate glycolytic intermediates via gluconeogenesis (GNG) in glucose-deprived conditions remains unknown. Here, we report that glucose-deprived ECs upregulate the GNG enzyme...
5.
Passi R, Cholewa-Waclaw J, Wereski R, Bennett M, Veizades S, Berkeley B, et al.
Vascul Pharmacol
. 2024 Jan;
154:107277.
PMID: 38266794
Background: COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect multiple organ systems, including the pulmonary vasculature. Endothelial cells (ECs) are thought to play a key role...
6.
Truong A, Becker L, Dekoning N, Bouche A, Veys K, Hosseinkhani B, et al.
MethodsX
. 2023 Nov;
11:102446.
PMID: 37928105
Angiogenesis and lymphangiogenesis, the formation of new blood or lymphatic vessels, respectively, from preexisting vasculature is essential during embryonic development, but also occurs during tissue repair and in pathological conditions...
7.
Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, et al.
Cell Death Dis
. 2023 Sep;
14(9):600.
PMID: 37684238
Intracellular Ca signals control several physiological and pathophysiological processes. The main tool to chelate intracellular Ca is intracellular BAPTA (BAPTA), usually introduced into cells as a membrane-permeant acetoxymethyl ester (BAPTA-AM)....
8.
Lee C, Chen R, Sun G, Liu X, Lin X, He C, et al.
Signal Transduct Target Ther
. 2023 Aug;
8(1):305.
PMID: 37591843
Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs...
9.
Sokol L, Cuypers A, Truong A, Bouche A, Brepoels K, Souffreau J, et al.
Commun Biol
. 2023 Jun;
6(1):648.
PMID: 37330599
Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional...
10.
Cuypers A, Teuwen L, Bridgeman V, de Rooij L, Eelen G, Dewerchin M, et al.
STAR Protoc
. 2022 Sep;
3(4):101691.
PMID: 36173713
Tumor vessel co-option, a process in which cancer cells "hijack" pre-existing blood vessels to grow and invade healthy tissue, is poorly understood but is a proposed resistance mechanism against anti-angiogenic...