Letizia Pruccoli
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Explore the profile of Letizia Pruccoli including associated specialties, affiliations and a list of published articles.
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32
Citations
302
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Recent Articles
1.
Pereira R, Campos H, de Oliveira Ferreira P, Uchenna N, Silva Y, Okoh V, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Oct;
PMID: 39414701
Chrysin (CHR) is a naturally occurring flavonoid found in the human diet, recognized for its potential in preventing neurodegenerative diseases. However, its limited water solubility restricts its bioavailability and therapeutic...
2.
de Freitas Silva M, Juliet Cristancho Ortiz C, Ferreira Coelho L, Pruccoli L, Pagliarani B, Pisani L, et al.
Bioorg Chem
. 2024 Jun;
150:107587.
PMID: 38941700
Molecular hybridization between structural fragments from the structures of curcumin (1) and resveratrol (2) was used as a designing tool to generate a new N-acyl-cinnamoyl-hydrazone hybrid molecular architecture. Twenty-eight new...
3.
Pruccoli L, Balducci M, Pagliarani B, Tarozzi A
Curr Issues Mol Biol
. 2024 Jun;
46(6):5984-5998.
PMID: 38921028
Fucoxanthin is the most abundant carotenoid found in marine brown algae that exhibits several healthy properties. Dietary fucoxanthin is metabolized in the intestine, plasma, and other tissues to various metabolites,...
4.
Campos H, Pereira R, de Oliveira Ferreira P, Uchenna N, Branco da Silva C, Pruccoli L, et al.
Chem Biol Interact
. 2024 Apr;
395:111026.
PMID: 38679115
In the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach...
5.
Pruccoli L, Nicolini B, Lianza M, Teti G, Falconi M, Tarozzi A, et al.
Plants (Basel)
. 2024 Apr;
13(6).
PMID: 38592786
L. is a typical European-Mediterranean species of the genus Teucrium. Among the phenolic compounds belonging to phenylethanoid glycosides (PGs), teucrioside (TS) is only found in this species, and it was...
6.
Guardigni M, Pruccoli L, Santini A, De Simone A, Bersani M, Spyrakis F, et al.
ACS Chem Neurosci
. 2023 May;
14(11):1963-1970.
PMID: 37218653
Glycogen synthase kinase 3β (GSK-3β) is a serine/threonine kinase and an attractive therapeutic target for Alzheimer's disease. Based on proteolysis-targeting chimera (PROTAC) technology, a small set of novel GSK-3β degraders...
7.
De Lorenzi E, Seghetti F, Tarozzi A, Pruccoli L, Contardi C, Serra M, et al.
Eur J Med Chem
. 2023 Mar;
252:115297.
PMID: 36996713
Simultaneous modulation of multifaceted toxicity arising from neuroinflammation, oxidative stress, and mitochondrial dysfunction represents a valuable therapeutic strategy to tackle Alzheimer's disease. Among the significant hallmarks of the disorder, Aβ...
8.
Zuccarini M, Pruccoli L, Balducci M, Giuliani P, Caciagli F, Ciccarelli R, et al.
J Clin Med
. 2023 Feb;
12(3).
PMID: 36769818
The production of reactive oxygen species (ROS) in the brain is homeostatically controlled and contributes to normal neural functions. Inefficiency of control mechanisms in brain aging or pathological conditions leads...
9.
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimaraes M, Motta R da Silva F, Castro N, et al.
Bioorg Med Chem
. 2022 Aug;
71:116952.
PMID: 35930852
The search for new drug candidates against Alzheimer's disease (AD) remains a complex challenge for medicinal chemists due to its multifactorial pathogenesis and incompletely understood physiopathology. In this context, we...
10.
Juliet Cristancho Ortiz C, de Freitas Silva M, Pruccoli L, Nadur N, de Azevedo L, Kummerle A, et al.
RSC Med Chem
. 2022 Jun;
13(5):568-584.
PMID: 35694691
A new series of eight multifunctional thalidomide-donepezil hybrids were synthesized based on the multi-target-directed ligand strategy and evaluated as potential neuroprotective, cholinesterase inhibitors and anti-neuroinflammatory agents against neurodegenerative diseases. A...