Andrea Tarozzi
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Explore the profile of Andrea Tarozzi including associated specialties, affiliations and a list of published articles.
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76
Citations
1100
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Recent Articles
1.
Balducci M, Perez J, Del Rio C, Perez M, Carranza A, Gomez Escribano A, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596283
Several neurodegenerative diseases (NDDs), such as Huntington's disease, six of the spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, and spinobulbar muscular atrophy, are caused by abnormally long polyglutamine (polyQ) tracts. Natural compounds capable...
2.
Pereira R, Campos H, de Oliveira Ferreira P, Uchenna N, Silva Y, Okoh V, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Oct;
PMID: 39414701
Chrysin (CHR) is a naturally occurring flavonoid found in the human diet, recognized for its potential in preventing neurodegenerative diseases. However, its limited water solubility restricts its bioavailability and therapeutic...
3.
de Freitas Silva M, Juliet Cristancho Ortiz C, Ferreira Coelho L, Pruccoli L, Pagliarani B, Pisani L, et al.
Bioorg Chem
. 2024 Jun;
150:107587.
PMID: 38941700
Molecular hybridization between structural fragments from the structures of curcumin (1) and resveratrol (2) was used as a designing tool to generate a new N-acyl-cinnamoyl-hydrazone hybrid molecular architecture. Twenty-eight new...
4.
Pruccoli L, Balducci M, Pagliarani B, Tarozzi A
Curr Issues Mol Biol
. 2024 Jun;
46(6):5984-5998.
PMID: 38921028
Fucoxanthin is the most abundant carotenoid found in marine brown algae that exhibits several healthy properties. Dietary fucoxanthin is metabolized in the intestine, plasma, and other tissues to various metabolites,...
5.
Santini A, Tassinari E, Poeta E, Loi M, Ciani E, Trazzi S, et al.
ACS Chem Neurosci
. 2024 May;
15(11):2099-2111.
PMID: 38747979
Despite recent FDA approvals, Alzheimer's disease (AD) still represents an unmet medical need. Among the different available therapeutic approaches, the development of multitarget molecules represents one of the most widely...
6.
Campos H, Pereira R, de Oliveira Ferreira P, Uchenna N, Branco da Silva C, Pruccoli L, et al.
Chem Biol Interact
. 2024 Apr;
395:111026.
PMID: 38679115
In the pursuit of novel antioxidant therapies for the prevention and treatment of neurodegenerative diseases, three new arylpiperazine derivatives (LQFM181, LQFM276, and LQFM277) were synthesized through a molecular hybridization approach...
7.
Pruccoli L, Nicolini B, Lianza M, Teti G, Falconi M, Tarozzi A, et al.
Plants (Basel)
. 2024 Apr;
13(6).
PMID: 38592786
L. is a typical European-Mediterranean species of the genus Teucrium. Among the phenolic compounds belonging to phenylethanoid glycosides (PGs), teucrioside (TS) is only found in this species, and it was...
8.
Okoh V, Campos H, de Oliveira Ferreira P, Pereira R, Silva Y, Arruda E, et al.
J Pharm Pharmacol
. 2024 Feb;
76(4):368-380.
PMID: 38330395
Objectives: To evaluate whether the glycosylation of chrysin (CHR) enhances its protective effects against aluminum-induced neurotoxicity. Methods: To compare the antioxidant, anticholinesterase, and behavioral effects of CHR with its glycosylated...
9.
Guardigni M, Pruccoli L, Santini A, De Simone A, Bersani M, Spyrakis F, et al.
ACS Chem Neurosci
. 2023 May;
14(11):1963-1970.
PMID: 37218653
Glycogen synthase kinase 3β (GSK-3β) is a serine/threonine kinase and an attractive therapeutic target for Alzheimer's disease. Based on proteolysis-targeting chimera (PROTAC) technology, a small set of novel GSK-3β degraders...
10.
De Lorenzi E, Seghetti F, Tarozzi A, Pruccoli L, Contardi C, Serra M, et al.
Eur J Med Chem
. 2023 Mar;
252:115297.
PMID: 36996713
Simultaneous modulation of multifaceted toxicity arising from neuroinflammation, oxidative stress, and mitochondrial dysfunction represents a valuable therapeutic strategy to tackle Alzheimer's disease. Among the significant hallmarks of the disorder, Aβ...