Isabella Alvim Guedes
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Explore the profile of Isabella Alvim Guedes including associated specialties, affiliations and a list of published articles.
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12
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61
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Recent Articles
1.
Guedes I, Pereira da Silva M, Galheigo M, Krempser E, de Magalhaes C, Correa Barbosa H, et al.
J Mol Biol
. 2024 Sep;
436(17):168548.
PMID: 39237203
The DockThor-VS platform (https://dockthor.lncc.br/v2/) is a free protein-ligand docking server conceptualized to facilitate and assist drug discovery projects to perform docking-based virtual screening experiments accurately and using high-performance computing. The...
2.
Bellini R, Guedes I, Ciapina L, de Vasconcelos A, Dardenne L, Nicolas M
Mem Inst Oswaldo Cruz
. 2022 Sep;
117:e220102.
PMID: 36169569
Background: Gram-negative and Gram-positive bacteria produce beta-lactamase as factors to overcome beta-lactam antibiotics, causing their hydrolysis and impaired antimicrobial action. Class A beta-lactamase contains the chromosomal sulfhydryl reagent variable (SHV,...
3.
Silva D, Beltrame C, Botelho A, Martini C, Esteves M, Guedes I, et al.
Antibiotics (Basel)
. 2022 Sep;
11(9).
PMID: 36139996
Multidrug resistance is commonly acquired by transferring DNA from one bacterium to another. However, the mechanisms that enhance the acquisitions of foreign genes are poorly understood, as well as the...
4.
Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge R Guimaraes M, Motta R da Silva F, Castro N, et al.
Bioorg Med Chem
. 2022 Aug;
71:116952.
PMID: 35930852
The search for new drug candidates against Alzheimer's disease (AD) remains a complex challenge for medicinal chemists due to its multifactorial pathogenesis and incompletely understood physiopathology. In this context, we...
5.
Juliet Cristancho Ortiz C, de Freitas Silva M, Pruccoli L, Nadur N, de Azevedo L, Kummerle A, et al.
RSC Med Chem
. 2022 Jun;
13(5):568-584.
PMID: 35694691
A new series of eight multifunctional thalidomide-donepezil hybrids were synthesized based on the multi-target-directed ligand strategy and evaluated as potential neuroprotective, cholinesterase inhibitors and anti-neuroinflammatory agents against neurodegenerative diseases. A...
6.
Juliet Cristancho Ortiz C, Damasio C, Pruccoli L, Nadur N, de Azevedo L, Guedes I, et al.
Neurochem Res
. 2020 Oct;
45(12):3003-3020.
PMID: 33079324
A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was synthesized and evaluated as multifunctional ligands against neurodegenerative diseases. The molecular hybridization approach was based on the combination of 1-benzyl-4-piperidine fragment...
7.
Lopes J, Silva L, Ceschi M, Ludtke D, Zimmer A, Ruaro T, et al.
Medchemcomm
. 2020 Sep;
10(12):2089-2101.
PMID: 32904099
In this study, we synthesized nine novel hybrids derived from d-xylose, d-ribose, and d-galactose sugars connected by a methylene chain with lophine. The compounds were synthesized by a four-component reaction...
8.
de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro N, Jorge R Guimaraes M, da Silva F, et al.
Molecules
. 2020 Jul;
25(14).
PMID: 32664425
(AD) is a neurodegenerative disorder that involves different pathogenic mechanisms. In this regard, the goal of this study was the design and synthesis of new compounds with multifunctional pharmacological activity...
9.
Lopes J, Silva L, da Costa Franarin G, Ceschi M, Ludtke D, Dantas R, et al.
Bioorg Med Chem
. 2018 Oct;
26(20):5566-5577.
PMID: 30340901
A series of hybrids containing tacrine linked to carbohydrate-based moieties, such as d-xylose, d-ribose, and d-galactose derivatives, were synthesized by the nucleophilic substitution between 9-aminoalkylamino-1,2,3,4-tetrahydroacridines and the corresponding sugar-based tosylates....
10.
Dias Viegas F, de Freitas Silva M, da Rocha M, Castelli M, Riquiel M, Machado R, et al.
Eur J Med Chem
. 2018 Feb;
147:48-65.
PMID: 29421570
A new series of sixteen multifunctional N-benzyl-piperidine-aryl-acylhydrazones hybrid derivatives was synthesized and evaluated for multi-target activities related to Alzheimer's disease (AD). The molecular hybridization approach was based on the combination,...