Leonard Petrucelli
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Explore the profile of Leonard Petrucelli including associated specialties, affiliations and a list of published articles.
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289
Citations
19893
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Recent Articles
1.
Sheth U, Oijerstedt L, Heckman M, White L, Heuer H, Lario Lago A, et al.
Mol Neurodegener
. 2025 Mar;
20(1):30.
PMID: 40075459
Background: Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood glial fibrillary acidic protein (GFAP) has...
2.
Madden B, Polania-Sandoval C, Pujari G, Mangalaparthi K, Charlesworth M, Prudencio M, et al.
JVS Vasc Sci
. 2025 Mar;
6:100281.
PMID: 40034248
Objective: Extracranial carotid artery pathology accounts for 15% to 20% of ischemic strokes. Advancements in magnetic resonance angiography (MRA) with vessel wall imaging (VWI) have enabled the identification of vulnerable...
3.
Rajbanshi B, Prufer Q C Araujo I, VandeVrede L, Ljubenkov P, Staffaroni A, Heuer H, et al.
Alzheimers Dement (Amst)
. 2025 Jan;
17(1):e70078.
PMID: 39886325
Introduction: Plasma amyloid beta/amyloid beta (Aβ/Aβ) and phosphorylated tau217 (p-tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co-pathology in the setting of other primary neurodegenerative diseases,...
4.
Polania-Sandoval C, Byeon S, Hartwell J, Prudencio M, Petrucelli L, Brigham T, et al.
Ann Vasc Surg
. 2025 Jan;
113:83-94.
PMID: 39855383
Background: Lipids are key molecules for atherosclerosis, with tight regulation mechanisms, making them potential biomarkers for disease-specific diagnostics and therapeutics. Therefore, we aim to perform a systematic literature review on...
5.
Valenzuela V, Becerra D, Astorga J, Fuentealba M, Diaz G, Bargsted L, et al.
Mol Ther
. 2025 Jan;
33(3):1226-1245.
PMID: 39799393
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting in a combinatory of motor and cognitive symptoms and...
6.
Pickles S, Gonzalez Bejarano J, Narayan A, Daughrity L, Maroto Cidfuentes C, Reeves M, et al.
Mov Disord
. 2025 Jan;
PMID: 39788898
Background: Perry syndrome (PS) is a rare and fatal hereditary autosomal dominant neurodegenerative disorder caused by mutations in dynactin (DCTN1). PS brains accumulate inclusions positive for ubiquitin, transactive-response DNA-binding protein...
7.
Kempthorne L, Vaizoglu D, Cammack A, Carcole M, Roberts M, Mikheenko A, et al.
Nat Commun
. 2025 Jan;
16(1):459.
PMID: 39779704
The most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is an intronic GC repeat expansion in C9orf72. The repeats undergo bidirectional transcription to produce sense...
8.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar N, Feederle R, et al.
Cell Rep
. 2024 Dec;
44(1):115107.
PMID: 39709600
Genetic variants in TMEM106B, coding for a transmembrane protein of unknown function, have been identified as critical genetic modulators in various neurodegenerative diseases with a strong effect in patients with...
9.
Udine E, Finch N, DeJesus-Hernandez M, Jackson J, Baker M, Saravanaperumal S, et al.
Mol Neurodegener
. 2024 Dec;
19(1):99.
PMID: 39709476
Background: The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this repeat expansion...
10.
Kokona B, Cunningham N, Quinn J, Jacobsen D, Garcia F, Galindo S, et al.
Anal Biochem
. 2024 Nov;
697:115720.
PMID: 39581338
Sedimentation velocity, using an analytical ultracentrifuge equipped with fluorescence detection, and electrophoresis methods are used to study aggregation of proteins in transgenic animal model systems. Our previous work validated the...