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Ronald C Petersen

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Recent Articles
1.
Lavrova A, Pham N, Reid R, Boeve B, Knopman D, Petersen R, et al.
Neurobiol Aging . 2025 Mar; 150:97-108. PMID: 40088623
Transactive response DNA-binding protein 43 kDa (TDP-43) deposition is linked to regional brain atrophy in Alzheimer's disease (AD), but diffusion changes associated with AD-related TDP-43 proteinopathy remain underexplored. This study...
2.
Ghatamaneni S, Hruska C, Shin I, Bruinsma T, Scott N, Lee J, et al.
Acta Neuropathol . 2025 Mar; 149(1):26. PMID: 40085238
Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer's disease (AD). The maturity level of neurofibrillary tangles can affect its recognition...
3.
Stricker N, Frank R, Boots E, Fan W, Christianson T, Kremers W, et al.
Clin Neuropsychol . 2025 Mar; :1-30. PMID: 40069913
Few normative data for unsupervised, remotely-administered computerized cognitive measures are available. We examined variables to include in normative models for Mayo Test Drive (MTD, a multi-device remote cognitive assessment platform)...
4.
Singh-Reilly N, Pham N, Graff-Radford J, Machulda M, Spychalla A, Senjem M, et al.
Neurobiol Aging . 2025 Mar; 150:44-52. PMID: 40056539
Dementia with Lewy bodies (DLB) and posterior cortical atrophy (PCA) are neurodegenerative disorders that can overlap clinically and in patterns of regional hypometabolism and show elevated white matter hyperintensity (WMH)...
5.
Cogswell P, Wiste H, Weigand S, Therneau T, Griswold M, Braunstein J, et al.
Alzheimers Dement . 2025 Feb; 21(2):e14629. PMID: 39989078
Introduction: Limited data exist on the utility of plasma biomarkers to predict incident abnormal amyloid positron emission tomography (PET). In this study we evaluate the association of plasma Alzheimer's disease...
6.
Patel J, Christianson T, Monahan L, Frank R, Fan W, Stricker J, et al.
J Clin Exp Neuropsychol . 2025 Feb; :1-23. PMID: 39976252
Background: Mayo Test Drive (MTD): Mayo Test Development through Rapid Iteration, Validation and Expansion, is a web-based remote cognitive assessment platform for self-administered neuropsychological measures with previously demonstrated validity and...
7.
Youssef H, Gatto R, Pham N, Jones D, Petersen R, Machulda M, et al.
Neuropathology . 2025 Feb; PMID: 39973236
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, marked by abnormal protein buildup (beta-amyloid and tau) resulting in neuronal loss, especially in the medial temporal lobe...
8.
Jones K, Aakre J, Castillo A, Ramanan V, Kremers W, Jack Jr C, et al.
J Prev Alzheimers Dis . 2025 Feb; :100088. PMID: 39966022
The study aimed to assess eligibility for donanemab phase 3 trial in participants of the Mayo Clinic Study of Aging with mild cognitive impairment (MCI) or mild dementia consistent with...
9.
Ebner B, Erdahl S, Lundgreen C, Vassilaki M, Kremers W, Knopman D, et al.
Acta Neuropathol . 2025 Feb; 149(1):18. PMID: 39954128
We examined whether total joint arthroplasty (TJA) is associated with increased metal accumulation in the brain and histopathologic changes of Alzheimer's disease. We measured ultra-trace metal concentrations (aluminum, chromium, cobalt,...
10.
Petersen R, Graf A, Brady C, De Santi S, Florian H, Landen J, et al.
Alzheimers Dement (N Y) . 2025 Feb; 11(1):e70038. PMID: 39935618
Highlights: The Alzheimer's Association Research Roundtable (AARR) convened leaders from academia and industry as well as patients, care partners, clinicians, regulators, and payers to discuss the topic of operationalizing selection...