Kyle S Hoffman
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Explore the profile of Kyle S Hoffman including associated specialties, affiliations and a list of published articles.
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16
Citations
178
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Recent Articles
1.
Tennakoon R, Bily T, Hasan F, Syal S, Voigt A, Balci T, et al.
Mol Ther Nucleic Acids
. 2025 Feb;
36(1):102442.
PMID: 39897579
Huntington's disease (HD) is caused by polyglutamine (polyQ) repeat expansions in the huntingtin gene. HD-causative polyQ alleles lead to protein aggregation, which is a prerequisite for disease. Translation fidelity modifies...
2.
Wilhelm S, Kakadia J, Beharry A, Kenana R, Hoffman K, ODonoghue P, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):14043-14060.
PMID: 39530218
Aminoacyl-tRNA synthetases are indispensable enzymes in all cells, ensuring the correct pairing of amino acids to their cognate tRNAs to maintain translation fidelity. Autosomal dominant mutations V133F and Y330C in...
3.
Manara P, Newsam A, Saralamma V, Russo M, Martinez A, Fattakhov N, et al.
bioRxiv
. 2024 Sep;
PMID: 39314323
Cancers coopt stress-response pathways to drive oncogenesis, dodge immune surveillance, and resist cytotoxic therapies. Several of these provide protection from ferroptosis, iron-mediated oxidative cell death. Here, we found dramatic sensitization...
4.
Davey-Young J, Hasan F, Tennakoon R, Rozik P, Moore H, Hall P, et al.
RNA Biol
. 2024 Apr;
21(1):1-23.
PMID: 38629491
Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases....
5.
Hoffman K, Chung C, Mukai T, Krahn N, Jiang H, Balasuriya N, et al.
RNA
. 2023 Jun;
29(9):1400-1410.
PMID: 37279998
Unique chemical and physical properties are introduced by inserting selenocysteine (Sec) at specific sites within proteins. Recombinant and facile production of eukaryotic selenoproteins would benefit from a yeast expression system;...
6.
Schuntermann D, Fischer J, Bile J, Gaier S, Shelley B, Awawdeh A, et al.
J Biol Chem
. 2023 May;
299(7):104852.
PMID: 37224963
The correct coupling of amino acids with transfer RNAs (tRNAs) is vital for translating genetic information into functional proteins. Errors during this process lead to mistranslation, where a codon is...
7.
Hoffman K, Humphrey N, Korslund J, Anderson T, Faaberg K, Lager K, et al.
Front Vet Sci
. 2022 Jul;
9:923878.
PMID: 35812884
Vesicular disease caused by Senecavirus A (SVA) is clinically indistinguishable from foot-and-mouth disease (FMD) and other vesicular diseases of swine. When a vesicle is observed in FMD-free countries, a costly...
8.
McCann H, Lake B, Hoffman K, Davola M, Mossman K, Rullo A
ACS Chem Biol
. 2022 May;
17(5):1269-1281.
PMID: 35522208
Covalent antibody recruiting molecules (cARMs) constitute a proximity-inducing chemical strategy to modulate the recognition and elimination of cancer cells by the immune system. Recognition is achieved through synthetic bifunctional molecules...
9.
Vargas-Rodriguez O, Badran A, Hoffman K, Chen M, Crnkovic A, Ding Y, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(35).
PMID: 34413202
Inaccurate expression of the genetic code, also known as mistranslation, is an emerging paradigm in microbial studies. Growing evidence suggests that many microbial pathogens can deliberately mistranslate their genetic code...
10.
Ad O, Hoffman K, Cairns A, Featherston A, Miller S, Soll D, et al.
ACS Cent Sci
. 2019 Aug;
5(7):1289-1294.
PMID: 31403077
Here, we report that wild type ribosomes accept and elongate precharged initiator tRNAs acylated with multiple benzoic acids, including aramid precursors, as well as malonyl (1,3-dicarbonyl) substrates to generate a...