Takahito Mukai
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Explore the profile of Takahito Mukai including associated specialties, affiliations and a list of published articles.
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32
Citations
828
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Recent Articles
1.
Hoffman K, Chung C, Mukai T, Krahn N, Jiang H, Balasuriya N, et al.
RNA
. 2023 Jun;
29(9):1400-1410.
PMID: 37279998
Unique chemical and physical properties are introduced by inserting selenocysteine (Sec) at specific sites within proteins. Recombinant and facile production of eukaryotic selenoproteins would benefit from a yeast expression system;...
2.
Guo L, Amikura K, Jiang H, Mukai T, Fu X, Wang Y, et al.
J Biol Chem
. 2022 Sep;
298(11):102521.
PMID: 36152750
The pyrrolysyl-tRNA synthetase (PylRS) facilitates the cotranslational installation of the 22nd amino acid pyrrolysine. Owing to its tolerance for diverse amino acid substrates, and its orthogonality in multiple organisms, PylRS...
3.
Fujita H, Osaku A, Sakane Y, Yoshida K, Yamada K, Nara S, et al.
ACS Synth Biol
. 2022 Aug;
11(9):3088-3099.
PMID: 35998348
The physical stability of bacterial chromosomes is important for their in vitro manipulation, while genetic stability is important in vivo. However, extracted naked chromosomes in the open circular form are...
4.
Zhang H, Gong X, Zhao Q, Mukai T, Vargas-Rodriguez O, Zhang H, et al.
Nucleic Acids Res
. 2022 Apr;
50(8):4601-4615.
PMID: 35466371
Site-specific incorporation of distinct non-canonical amino acids into proteins via genetic code expansion requires mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. Pyrrolysyl-tRNA synthetase (PylRS)/tRNAPyl pairs are ideal for genetic code expansion and...
5.
Mukai T, Amikura K, Fu X, Soll D, Crnkovic A
Front Genet
. 2022 Jan;
12:794509.
PMID: 35047015
Universally present aminoacyl-tRNA synthetases (aaRSs) stringently recognize their cognate tRNAs and acylate them with one of the proteinogenic amino acids. However, some organisms possess aaRSs that deviate from the accurate...
6.
Mukai T
Int J Mol Sci
. 2021 Apr;
22(9).
PMID: 33925673
In bacteria, selenocysteine (Sec) is incorporated into proteins via the recoding of a particular codon, the UGA stop codon in most cases. Sec-tRNA is delivered to the ribosome by the...
7.
Yoneji T, Fujita H, Mukai T, Suetsugu M
Nucleic Acids Res
. 2021 Apr;
49(15):8407-8418.
PMID: 33907814
In bacterial synthetic biology, whole genome transplantation has been achieved only in mycoplasmas that contain a small genome and are competent for foreign genome uptake. In this study, we developed...
8.
Mukai T
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33096801
Reprogramming of the genetic code system is limited by the difficulty in creating new tRNA structures. Here, I developed translationally active tRNA variants tagged with a small hairpin RNA aptamer,...
9.
Mukai T, Yoneji T, Yamada K, Fujita H, Nara S, Suetsugu M
ACS Synth Biol
. 2020 May;
9(6):1315-1327.
PMID: 32459960
Although has been a popular tool for plasmid construction, this bacterium was believed to be "unsuitable" for constructing a large plasmid whose size exceeds 500 kilobases. We assumed that traditional...
10.
Hoffman K, Vargas-Rodriguez O, Bak D, Mukai T, Woodward L, Weerapana E, et al.
J Biol Chem
. 2019 Jul;
294(34):12855-12865.
PMID: 31296657
Selenocysteine (Sec) is the 21st genetically encoded amino acid in organisms across all domains of life. Although structurally similar to cysteine (Cys), the Sec selenol group has unique properties that...