Ilka U Heinemann
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Explore the profile of Ilka U Heinemann including associated specialties, affiliations and a list of published articles.
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50
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748
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Recent Articles
1.
Samuels T, Wu F, Mahmood M, Abuzaid W, Sun N, Moresco A, et al.
FEBS J
. 2024 Dec;
PMID: 39702998
Aminoacyl-tRNA synthetases catalyze the ligation of a specific amino acid to its cognate tRNA. The resulting aminoacyl-tRNAs are indispensable intermediates in protein biosynthesis, facilitating the precise decoding of the genetic...
2.
Wilhelm S, Kakadia J, Beharry A, Kenana R, Hoffman K, ODonoghue P, et al.
Nucleic Acids Res
. 2024 Nov;
52(22):14043-14060.
PMID: 39530218
Aminoacyl-tRNA synthetases are indispensable enzymes in all cells, ensuring the correct pairing of amino acids to their cognate tRNAs to maintain translation fidelity. Autosomal dominant mutations V133F and Y330C in...
3.
Wilhelm S, Moresco A, Rivero A, Siu V, Heinemann I
IUBMB Life
. 2024 Oct;
76(12):1125-1138.
PMID: 39352000
Heterozygous pathogenic variants in the histidyl-tRNA synthetase (HARS) gene are associated with Charcot-Marie-Tooth (CMT) type 2W disease, classified as an axonal peripheral neuropathy. To date, at least 60 variants causing...
4.
Soll D, ODonoghue P, Heinemann I
Front Genet
. 2024 Aug;
15:1468891.
PMID: 39205939
No abstract available.
5.
Frederick M, Nassef M, Borrelli M, Kuang S, Buensuceso A, More T, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jun;
1870(7):167312.
PMID: 38901649
Epithelial ovarian cancer (EOC) is highly lethal due to its unique metastatic characteristics. EOC spheroids enter a non-proliferative state, with hypoxic cores and reduced oncogenic signaling, all of which contribute...
6.
Ward C, Beharry A, Tennakoon R, Rozik P, Wilhelm S, Heinemann I, et al.
Chem Rev
. 2024 May;
124(12):7976-8008.
PMID: 38801719
Transfer ribonucleic acid (tRNA) therapeutics will provide personalized and mutation specific medicines to treat human genetic diseases for which no cures currently exist. The tRNAs are a family of adaptor...
7.
Siddika T, Shao R, Heinemann I, ODonoghue P
IUBMB Life
. 2024 May;
76(9):632-646.
PMID: 38738523
Protein kinase B (AKT1) is a serine/threonine kinase that regulates fundamental cellular processes, including cell survival, proliferation, and metabolism. AKT1 activity is controlled by two regulatory phosphorylation sites (Thr308, Ser473)...
8.
Missense suppressor tRNA therapeutics correct disease-causing alleles by misreading the genetic code
Bily T, Heinemann I, ODonoghue P
Mol Ther
. 2024 Jan;
32(2):273-274.
PMID: 38219738
No abstract available.
9.
Kakadia J, Khalid M, Heinemann I, Han V
J Mol Endocrinol
. 2024 Jan;
72(3).
PMID: 38194365
Mechanisms underlying limitations in glucose supply that restrict fetal growth are not well established. IGF-1 is an important regulator of fetal growth and IGF-1 bioavailability is markedly inhibited by IGFBP-1...
10.
Frederick M, Hovey O, Kakadia J, Shepherd T, Li S, Heinemann I
Mol Cell Proteomics
. 2023 Oct;
22(11):100660.
PMID: 37820923
Epithelial ovarian cancer (EOC) is a high-risk cancer presenting with heterogeneous tumors. The high incidence of EOC metastasis from primary tumors to nearby tissues and organs is a major driver...