Julie Genereaux
Overview
Explore the profile of Julie Genereaux including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
295
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0
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Recent Articles
1.
Chadwick S, Stack-Couture S, Berg M, Di Gregorio S, Lung B, Genereaux J, et al.
Mol Biol Cell
. 2024 Dec;
36(2):ar13.
PMID: 39661468
Cells counter accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) through activation of the Unfolded Protein Response (UPR). Small molecules termed chemical chaperones can promote protein folding to...
2.
Davey-Young J, Hasan F, Tennakoon R, Rozik P, Moore H, Hall P, et al.
RNA Biol
. 2024 Apr;
21(1):1-23.
PMID: 38629491
Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases....
3.
Cozma E, Rao M, Dusick M, Genereaux J, Rodriguez-Mias R, Villen J, et al.
RNA Biol
. 2023 Sep;
20(1):791-804.
PMID: 37776539
Transfer RNAs (tRNAs) maintain translation fidelity through accurate charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid...
4.
Bari K, Berg M, Genereaux J, Brandl C, Lajoie P
G3 (Bethesda)
. 2022 Oct;
13(1).
PMID: 36315064
Gene expression undergoes considerable changes during the aging process. The mechanisms regulating the transcriptional response to cellular aging remain poorly understood. Here, we employ the budding yeast Saccharomyces cerevisiae to...
5.
Berg M, Zhu Y, Loll-Krippleber R, San Luis B, Genereaux J, Boone C, et al.
G3 (Bethesda)
. 2022 May;
12(7).
PMID: 35587152
Transfer RNA variants increase the frequency of mistranslation, the misincorporation of an amino acid not specified by the "standard" genetic code, to frequencies approaching 10% in yeast and bacteria. Cells...
6.
Razzaq I, Berg M, Jiang Y, Genereaux J, Uthayakumar D, Kim G, et al.
Genetics
. 2021 Dec;
219(2).
PMID: 34849885
Candida albicans is the most common cause of death from fungal infections. The emergence of resistant strains reducing the efficacy of first-line therapy with echinocandins, such as caspofungin calls for...
7.
Berg M, Isaacson J, Cozma E, Genereaux J, Lajoie P, Villen J, et al.
ACS Synth Biol
. 2021 Nov;
10(11):3177-3189.
PMID: 34726901
Transfer RNA (tRNA) variants that alter the genetic code increase protein diversity and have many applications in synthetic biology. Since the tRNA variants can cause a loss of proteostasis, regulating...
8.
Berg M, Zhu Y, Ruiz B, Loll-Krippleber R, Isaacson J, San Luis B, et al.
G3 (Bethesda)
. 2021 Sep;
11(10).
PMID: 34568909
Mistranslation, the misincorporation of an amino acid not specified by the "standard" genetic code, occurs in all organisms. tRNA variants that increase mistranslation arise spontaneously and engineered tRNAs can achieve...
9.
Berg M, Zhu Y, Isaacson J, Genereaux J, Loll-Krippleber R, Brown G, et al.
G3 (Bethesda)
. 2020 Oct;
10(12):4335-4345.
PMID: 33082270
Non-proteinogenic amino acids, such as the proline analog L-azetidine-2-carboxylic acid (AZC), are detrimental to cells because they are mis-incorporated into proteins and lead to proteotoxic stress. Our goal was to...
10.
Berg M, Zhu Y, Genereaux J, Ruiz B, Rodriguez-Mias R, Allan T, et al.
Genetics
. 2019 Sep;
213(3):849-863.
PMID: 31484688
Transfer RNAs (tRNAs) read the genetic code, translating nucleic acid sequence into protein. For tRNA the anticodon does not specify its aminoacylation. For this reason, mutations in the tRNA anticodon...