Kiyotsugu Yoshida
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Explore the profile of Kiyotsugu Yoshida including associated specialties, affiliations and a list of published articles.
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90
Citations
3199
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Recent Articles
11.
Takano Y, Yogosawa S, Imaizumi Y, Kamioka H, Kanegae Y, Eto K, et al.
Cancer Sci
. 2023 Sep;
114(12):4558-4570.
PMID: 37776195
Dual-specificity tyrosine-regulated kinase 2 (DYRK2) is a protein kinase that phosphorylates p53-Ser46 and induces apoptosis in response to DNA damage. However, the relationship between DYRK2 expression and chemosensitivity after DNA...
12.
Yoshida S, Yoshida K
Genes Dis
. 2023 Jul;
10(3):758-770.
PMID: 37396550
The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the protein activation state, cellular localization, and...
13.
Kamioka H, Yogosawa S, Oikawa T, Aizawa D, Ueda K, Saeki C, et al.
JHEP Rep
. 2023 Jun;
5(7):100759.
PMID: 37333975
Background & Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and has a poor prognosis. However, the molecular mechanisms underlying hepatocarcinogenesis and progression remain unknown. gain-...
14.
Yamada K, Hannya Y, Oikawa T, Yoshida A, Katagiri K, Yoshida S, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241771
Extended-synaptotagmin 1 (E-Syt1) is an endoplasmic reticulum membrane protein that is involved in cellular lipid transport. Our previous study identified E-Syt1 as a key factor for the unconventional protein secretion...
15.
Yamada K, Yoshida K
DNA Cell Biol
. 2023 Mar;
42(5):225-228.
PMID: 36930842
Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. Several previous studies on...
16.
Shimoyama Y, Yamada K, Yoshida S, Kawamura A, Hannya Y, Imaizumi Y, et al.
Cancer Sci
. 2023 Feb;
114(6):2471-2484.
PMID: 36851883
Protein kinase C delta (PKCδ) is a multifunctional serine-threonine kinase implicated in cell proliferation, differentiation, tumorigenesis, and therapeutic resistance. However, the molecular mechanism of PKCδ in colorectal cancer (CRC) remains...
17.
18.
Yamada K, Motohashi S, Oikawa T, Tago N, Koizumi R, Ono M, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2202730119.
PMID: 36044553
Protein secretion in cancer cells defines tumor survival and progression by orchestrating the microenvironment. Studies suggest the occurrence of active secretion of cytosolic proteins in liver cancer and their involvement...
19.
Kawamura A, Yoshida S, Aoki K, Shimoyama Y, Yamada K, Yoshida K
J Cell Sci
. 2022 May;
135(11).
PMID: 35582972
Neural precursor cell-expressed developmentally down-regulated 8 (NEDD8), an ubiquitin-like protein, is an essential regulator of the DNA damage response. Numerous studies have shown that neddylation (conjugation of NEDD8 to target...
20.
Yamada K, Kizawa R, Yoshida A, Koizumi R, Motohashi S, Shimoyama Y, et al.
Cancer Sci
. 2022 May;
113(7):2378-2385.
PMID: 35490382
Protein kinase C delta (PKCδ) is a multifunctional PKC family member and has been implicated in many types of cancers, including liver cancer. Recently, we have reported that PKCδ is...