Kohji Yamada
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Explore the profile of Kohji Yamada including associated specialties, affiliations and a list of published articles.
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44
Citations
1427
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Recent Articles
1.
Ueda K, Oikawa T, Yamada K, Tsubota A, Saeki C, Katagiri K, et al.
Biochem Biophys Res Commun
. 2025 Feb;
751:151431.
PMID: 39908908
Protein kinase C delta (PKCδ) is a leaderless protein generally localized in the cytoplasm and nucleus; however, its extracellular unconventional protein secretion occurs exclusively in hepatocellular carcinoma (HCC) cells (but...
2.
Oikawa T, Yamada K, Tsubota A, Saeki C, Tago N, Nakagawa C, et al.
Gastro Hep Adv
. 2024 Aug;
2(1):83-95.
PMID: 39130149
Backgrounds And Aims: Hepatocellular carcinoma (HCC) is the most common cancer with a poor prognosis. Identification of an alternative biomarker that can detect early-stage and conventional tumor marker-negative HCC is...
3.
Yoshida S, Kawamura A, Aoki K, Wiriyasermkul P, Sugimoto S, Tomiyoshi J, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(28):e2320070121.
PMID: 38968120
Hedgehog (Hh) signaling, an evolutionarily conserved pathway, plays an essential role in development and tumorigenesis, making it a promising drug target. Multiple negative regulators are known to govern Hh signaling;...
4.
Nakagawa C, Oikawa T, Yamada K, Tsubota A, Saeki C, Katagiri K, et al.
Biomarkers
. 2024 Feb;
29(2):55-67.
PMID: 38361436
Background: The conventional markers for hepatocellular carcinoma (HCC), α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), have several limitations; both have low sensitivity in patients with early-stage HCC; low sensitivity for AFP...
5.
Yamada K, Mine A
Sci Adv
. 2024 Jan;
10(4):eadk4131.
PMID: 38266087
Pathogen recognition triggers energy-intensive defense systems. Although successful defense should depend on energy availability, how metabolic information is communicated to defense remains unclear. We show that sugar, especially glucose-6-phosphate (G6P),...
6.
Yamada K, Hannya Y, Oikawa T, Yoshida A, Katagiri K, Yoshida S, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241771
Extended-synaptotagmin 1 (E-Syt1) is an endoplasmic reticulum membrane protein that is involved in cellular lipid transport. Our previous study identified E-Syt1 as a key factor for the unconventional protein secretion...
7.
Inoue Y, Vy T, Singkaravanit-Ogawa S, Zhang R, Yamada K, Ogawa T, et al.
New Phytol
. 2023 Mar;
238(4):1578-1592.
PMID: 36939621
The hemibiotrophic fungal plant pathogen Colletotrichum orbiculare is predicted to secrete hundreds of effector proteins when the pathogen infects cucurbit crops, such as cucumber and melon, and tobacco (Nicotiana benthamiana),...
8.
Yamada K, Yoshida K
DNA Cell Biol
. 2023 Mar;
42(5):225-228.
PMID: 36930842
Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. Several previous studies on...
9.
Shimoyama Y, Yamada K, Yoshida S, Kawamura A, Hannya Y, Imaizumi Y, et al.
Cancer Sci
. 2023 Feb;
114(6):2471-2484.
PMID: 36851883
Protein kinase C delta (PKCδ) is a multifunctional serine-threonine kinase implicated in cell proliferation, differentiation, tumorigenesis, and therapeutic resistance. However, the molecular mechanism of PKCδ in colorectal cancer (CRC) remains...
10.