Naoe Taira
Overview
Explore the profile of Naoe Taira including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
380
Followers
0
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Recent Articles
1.
Taira N, Yamaguchi T, Kimura J, Lu Z, Fukuda S, Higashiyama S, et al.
Proc Natl Acad Sci U S A
. 2014 Jan;
111(2):717-22.
PMID: 24379358
Upon DNA damage, tumor suppressor p53 determines cell fate by repairing DNA lesions to survive or by inducing apoptosis to eliminate damaged cells. The decision is based on its posttranslational...
2.
Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, et al.
Cancer Lett
. 2013 Jun;
339(2):214-25.
PMID: 23791882
The epithelial-mesenchymal transition (EMT) plays a fundamental role in the early stages of breast cancer invasion. Snail, a zinc finger transcriptional repressor, is an important regulator of EMT. Snail is...
3.
Suzuki K, Dashzeveg N, Lu Z, Taira N, Miki Y, Yoshida K
Cancer Sci
. 2012 Jun;
103(10):1788-94.
PMID: 22712728
The cellular response to genotoxic stress is multifaceted in nature. Following DNA damage, the tumor suppressor gene p53 activates and plays critical roles in cell cycle arrest, activation of DNA...
4.
Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, et al.
J Clin Invest
. 2012 Feb;
122(3):859-72.
PMID: 22307329
Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this transition, and their aberrant expression...
5.
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
J Biol Chem
. 2009 Dec;
285(7):4909-19.
PMID: 19965871
The tumor suppressor p53 is a transcription factor that regulates cell cycle, DNA repair, senescence, and apoptosis in response to DNA damage. Phosphorylation of p53 at Ser-46 is indispensable for...
6.
Kimura J, Nguyen S, Liu H, Taira N, Miki Y, Yoshida K
Nucleic Acids Res
. 2008 Aug;
36(16):5250-9.
PMID: 18684994
Evasion from apoptotic cell death is a characteristic of cancer; genes that modulate this process may be optimal for therapeutic attack. Identifying key regulators of apoptosis is thus a central...
7.
Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K
Mol Cell
. 2007 Mar;
25(5):725-38.
PMID: 17349958
Genotoxic stress exerts biological activity by activating downstream effectors, including the p53 tumor suppressor. p53 regulates cell-cycle checkpoint and induction of apoptosis in response to DNA damage; however, molecular mechanisms...
8.
Yoshida K, Yamaguchi T, Shinagawa H, Taira N, Nakayama K, Miki Y
Mol Cell Biol
. 2006 Apr;
26(9):3414-31.
PMID: 16611985
DNA topoisomerase II is an essential nuclear enzyme that modulates DNA processes by altering the topological state of double-stranded DNA. This enzyme is required for chromosome condensation and segregation; however,...