New Insights into the Roles for DYRK Family in Mammalian Development and Congenital Diseases

Overview

Journal Genes Dis

Date 2023 Jul 3

PMID 37396550

Authors

Saishu Yoshida

Kiyotsugu Yoshida

Affiliations

Soon will be listed here.

Abstract

The dual-specificity tyrosine-regulated kinase (DYRK) family is evolutionarily conserved from invertebrate to mammals. DYRKs regulate cell proliferation, apoptosis, survival, and differentiation by modifying the protein activation state, cellular localization, and turnover. In contrast to several studies in cellular models, the available evidence regarding the roles of DYRKs in mammalian development is limited. This review summarizes the studies on which provide insight into their roles in mammalian tissue development and congenital diseases. evidence obtained using knockout and genetically modified animals helps to understand and develop novel clinical therapies and drug for human congenital diseases, such as Down syndrome and neuronal disorders (associated with DYRK1A) and skeletal ciliopathies (associated with DYRK2).

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