Kenzie D MacIsaac
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Explore the profile of Kenzie D MacIsaac including associated specialties, affiliations and a list of published articles.
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16
Citations
3127
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Recent Articles
1.
Liu H, Golji J, Brodeur L, Chung F, Chen J, deBeaumont R, et al.
Nat Med
. 2018 Dec;
25(1):95-102.
PMID: 30559422
Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases . Emerging data suggest that the strength and duration of IFN signaling can differentially impact...
2.
Zhang L, MacIsaac K, Zhou T, Huang P, Xin C, Dobson J, et al.
Mol Cancer Res
. 2017 Aug;
15(12):1722-1732.
PMID: 28851814
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated cancer characterized by a poor prognosis and a high level of lymphocyte infiltrate. Genetic hallmarks of NPC are not completely known...
3.
Guo Y, MacIsaac K, Chen Y, Miller R, Jain R, Joyce-Shaikh B, et al.
Cell Rep
. 2016 Dec;
17(12):3206-3218.
PMID: 28009290
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival...
4.
Bai J, Smock S, Jackson Jr G, MacIsaac K, Huang Y, Mankus C, et al.
PLoS One
. 2015 Feb;
10(2):e0118286.
PMID: 25706956
Objectives: Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were...
5.
MacIsaac K, Baumgartner R, Kang J, Loboda A, Peterfy C, DiCarlo J, et al.
PLoS One
. 2014 Dec;
9(12):e113937.
PMID: 25504080
Unlabelled: Approximately 30% of rheumatoid arthritis patients achieve inadequate response to anti-TNF biologics. Attempts to identify molecular biomarkers predicting response have met with mixed success. This may be attributable, in...
6.
MacIsaac K, Wang I, Menetski J, Roberts C
Drug Discov Today
. 2013 Oct;
19(2):133-9.
PMID: 24126144
The high failure rate of new therapeutic mechanisms tested in clinical development has spurred an upsurge in research dedicated to discovering biomarker readouts that can improve decision-making. Increasingly, systems biology...
7.
Derti A, Garrett-Engele P, MacIsaac K, Stevens R, Sriram S, Chen R, et al.
Genome Res
. 2012 Mar;
22(6):1173-83.
PMID: 22454233
We developed PolyA-seq, a strand-specific and quantitative method for high-throughput sequencing of 3' ends of polyadenylated transcripts, and used it to globally map polyadenylation (polyA) sites in 24 matched tissues...
8.
MacIsaac K, Fraenkel E
Methods Mol Biol
. 2010 Sep;
674:179-93.
PMID: 20827592
Chromatin immunoprecipitation (ChIP) experiments allow the location of transcription factors to be determined across the genome. Subsequent analysis of the sequences of the identified regions allows binding to be localized...
9.
MacIsaac K, Lo K, Gordon W, Motola S, Mazor T, Fraenkel E
PLoS Comput Biol
. 2010 May;
6(4):e1000773.
PMID: 20442865
Understanding the mechanistic basis of transcriptional regulation has been a central focus of molecular biology since its inception. New high-throughput chromatin immunoprecipitation experiments have revealed that most regulatory proteins bind...
10.
Odom D, Dowell R, Jacobsen E, Gordon W, Danford T, MacIsaac K, et al.
Nat Genet
. 2007 May;
39(6):730-2.
PMID: 17529977
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and...