David K Gifford
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Explore the profile of David K Gifford including associated specialties, affiliations and a list of published articles.
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94
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12916
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Recent Articles
1.
Abarinov V, Levine J, Churchill A, Hopwood B, Deiter C, Guney M, et al.
Genes Dev
. 2023 Jun;
37(11-12):490-504.
PMID: 37364986
The consolidation of unambiguous cell fate commitment relies on the ability of transcription factors (TFs) to exert tissue-specific regulation of complex genetic networks. However, the mechanisms by which TFs establish...
2.
Hamilton M, Fife J, Akinci E, Yu T, Khowpinitchai B, Cha M, et al.
Cell Genom
. 2023 May;
3(5):100304.
PMID: 37228746
Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and...
3.
Carter B, Huang P, Liu G, Liang Y, Lin P, Peng B, et al.
Front Immunol
. 2023 Mar;
14:1135815.
PMID: 36969239
Licensed COVID-19 vaccines ameliorate viral infection by inducing production of neutralizing antibodies that bind the SARS-CoV-2 Spike protein and inhibit viral cellular entry. However, the clinical effectiveness of these vaccines...
4.
Hamilton M, Fife J, Akinci E, Yu T, Khowpinitchai B, Cha M, et al.
bioRxiv
. 2023 Jan;
PMID: 36711952
Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and...
5.
Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels T, et al.
Nat Commun
. 2022 Sep;
13(1):5427.
PMID: 36109497
Neurons born in the embryo can undergo a protracted period of maturation lasting well into postnatal life. How gene expression changes are regulated during maturation and whether they can be...
6.
Saksena S, Liu G, Banholzer C, Horny G, Ewert S, Gifford D
Cell Rep Methods
. 2022 Jul;
2(7):100254.
PMID: 35880012
Effective biologics require high specificity and limited off-target binding, but these properties are not guaranteed by current affinity-selection-based discovery methods. Molecular counterselection against off targets is a technique for identifying...
7.
Huisman B, Dai Z, Gifford D, Birnbaum M
Elife
. 2022 Jul;
11.
PMID: 35781135
T cells play a critical role in the adaptive immune response, recognizing peptide antigens presented on the cell surface by major histocompatibility complex (MHC) proteins. While assessing peptides for MHC...
8.
Dai Z, Saksena S, Horny G, Banholzer C, Ewert S, Gifford D
Genome Res
. 2022 Jun;
32(9):1787-1794.
PMID: 35738900
The successful discovery of novel biological therapeutics by selection requires highly diverse libraries of candidate sequences that contain a high proportion of desirable candidates. Here we propose the use of...
9.
Krismer K, Hammelman J, Gifford D
Bioinformatics
. 2022 Feb;
38(9):2381-2388.
PMID: 35191481
Motivation: Sequence models based on deep neural networks have achieved state-of-the-art performance on regulatory genomics prediction tasks, such as chromatin accessibility and transcription factor binding. But despite their high accuracy,...
10.
Hammelman J, Krismer K, Gifford D
Nucleic Acids Res
. 2022 Jan;
50(9):e52.
PMID: 35100401
Genomic interactions provide important context to our understanding of the state of the genome. One question is whether specific transcription factor interactions give rise to genome organization. We introduce spatzie,...