Kathryn E Luker
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Explore the profile of Kathryn E Luker including associated specialties, affiliations and a list of published articles.
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93
Citations
2948
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Recent Articles
1.
Ciavattone N, Bevoor A, Farfel A, Rehman A, Ho K, Rock E, et al.
Sci Rep
. 2025 Feb;
15(1):5204.
PMID: 39939722
Patients with triple negative breast cancer (TNBC) show only modest response rates to immune checkpoint inhibitor immunotherapy, motivating ongoing efforts to identify approaches to boost efficacy. Using an immunocompetent mouse...
2.
Kinnunen P, Srivastava S, Wang Z, Ho K, Humphries B, Chen S, et al.
ArXiv
. 2024 Nov;
PMID: 39502887
Targeting signaling pathways that drive cancer cell migration or proliferation is a common therapeutic approach. A popular experimental technique, the scratch assay, measures the migration and proliferation-driven cell closure of...
3.
Schleh M, Ryan B, Ahn C, Ludzki A, Van Pelt D, Pitchford L, et al.
Acta Physiol (Oxf)
. 2024 Nov;
241(1):e14249.
PMID: 39487600
Aim: To examine factors underlying why most, but not all, adults with obesity exhibit impaired insulin-mediated glucose uptake, we compared: (1) adipose tissue fatty acid (FA) release, (2) skeletal muscle...
4.
Sinha S, Callow B, Farfel A, Roy S, Chen S, Masotti M, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39480488
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an...
5.
Kinnunen P, Humphries B, Luker G, Luker K, Linderman J
NPJ Syst Biol Appl
. 2024 Apr;
10(1):42.
PMID: 38637530
Single cancer cells within a tumor exhibit variable levels of resistance to drugs, ultimately leading to treatment failures. While tumor heterogeneity is recognized as a major obstacle to cancer therapy,...
6.
Sinha S, Farfel A, Luker K, Parker B, Yeung K, Luker G, et al.
PNAS Nexus
. 2024 Feb;
3(2):pgae014.
PMID: 38312224
Self-sufficiency (autonomy) in growth signaling, the earliest recognized hallmark of cancer, is fueled by the tumor cell's ability to "secrete-and-sense" growth factors (GFs); this translates into cell survival and proliferation...
7.
Robison T, Lee W, Luker K, Pettit K, Talpaz M, Chenevert T, et al.
Magn Reson Med
. 2024 Jan;
91(6):2568-2578.
PMID: 38265182
Purpose: Analyzing bone marrow in the hematologic cancer myelofibrosis requires endpoint histology in mouse models and bone marrow biopsies in patients. These methods hinder the ability to monitor therapy over...
8.
Zhou M, Ma Y, Rock E, Chiang C, Luker K, Luker G, et al.
Lab Chip
. 2023 Sep;
23(21):4619-4635.
PMID: 37750357
Cell migration is a complex process that plays a crucial role in normal physiology and pathologies such as cancer, autoimmune diseases, and mental disorders. Conventional cell migration assays face limitations...
9.
Schleh M, Ahn C, Ryan B, Chugh O, Luker A, Luker K, et al.
Am J Physiol Endocrinol Metab
. 2023 Sep;
325(5):E466-E479.
PMID: 37729021
Exercise training modifies lipid metabolism in skeletal muscle, but the effect of exercise training on intramyocellular lipid droplet (LD) abundance, size, and intracellular distribution in adults with obesity remains elusive....
10.
Sarma P, Carino C, Seetharama D, Pandey S, Dwivedi-Agnihotri H, Rui X, et al.
Nat Commun
. 2023 Aug;
14(1):4808.
PMID: 37558722
Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes...