Shuichi Takayama
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Explore the profile of Shuichi Takayama including associated specialties, affiliations and a list of published articles.
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224
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5706
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Recent Articles
1.
Battle D, Qiu X, Alex M, Rivers L, Hamilton J, Takayama S, et al.
Cells
. 2025 Mar;
14(5).
PMID: 40072078
Lipotoxicity, resulting from the buildup of excess lipids in non-adipose tissues, is increasingly recognized as a major contributor to the progression of kidney disease, highlighting the need for alternative models...
2.
Blondeel E, Peirsman A, Vermeulen S, Piccinini F, De Vuyst F, Estevao D, et al.
Sci Data
. 2025 Feb;
12(1):283.
PMID: 39962061
The application of three-dimensional (3D) cell cultures such as spheroids and organoids is growing in popularity both in academia and industry. However, morphology of the 3D architecture remains remarkably understudied....
3.
Chang J, Brew K, Hamilton J, Kumar V, Diaz J, Takayama S
Adv Healthc Mater
. 2025 Jan;
:e2403043.
PMID: 39887618
Vascular hypo-fibrinolysis is a historically underappreciated and understudied aspect of venous thromboembolism (VTE). This paper describes the development of a micro-clot dissolution assay for quantifying the fibrinolytic capacity of endothelial...
4.
Alegretti J, Rocha A, Nogueira-de-Souza N, Kato N, Barros B, Motta E, et al.
Cells
. 2025 Jan;
13(24.
PMID: 39768173
Classical preimplantation embryo culture is performed in static fluid environments. Whether a dynamic fluid environment, like the fallopian tube, is beneficial for embryo development remains to be determined across mammalian...
5.
Jiang N, Ying G, Yin Y, Guo J, Lozada J, Valdivia Padilla A, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2413684121.
PMID: 39541351
To mimic physiological microenvironments in organ-on-a-chip systems, physiologically relevant parameters are required to precisely access drug metabolism. Oxygen level is a critical microenvironmental parameter to maintain cellular or tissue functions...
6.
Lesher-Perez S, Vasani V, So J, Takayama S
Lab Chip
. 2024 Sep;
24(20):4798-4807.
PMID: 39291593
Pneumatic control mechanisms have long been integral to microfluidic systems, primarily using solenoid valves, pressurized gases, and vacuums to direct liquid flow. Despite advancements in liquid-driven self-regulated microfluidic circuits, gas-driven...
7.
Viola H, Chen L, Jo S, Washington K, Selva C, Li A, et al.
bioRxiv
. 2024 May;
PMID: 38798413
Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress towards therapeutics. Namely, high throughput therapeutic screening systems typically exclude...
8.
Lee J, LeCher J, Parigoris E, Shinagawa N, Sentosa J, Manfredi C, et al.
bioRxiv
. 2024 Jan;
PMID: 38260306
While breakthroughs with organoids have emerged as next-generation tools, standardization for drug discovery remains a challenge. This work introduces human airway organoids with reversed biopolarity (AORBs), cultured and analyzed in...
9.
Huang Y, Lee S, Liu W, Takayama S, Jia S
Rev Sci Instrum
. 2023 Dec;
94(12).
PMID: 38126811
Mechanical forces have increasingly been recognized as a key regulator in the fate of cellular development and functionality. Different mechanical transduction methods, such as substrate stiffness and magnetic bead vibration,...
10.
Viola H, Vasani V, Washington K, Lee J, Selva C, Li A, et al.
Lab Chip
. 2023 Dec;
24(2):197-209.
PMID: 38093669
This paper introduces a two-inlet, one-outlet lung-on-a-chip device with semi-circular cross-section microchannels and computer-controlled fluidic switching that enables a broader systematic investigation of liquid plug dynamics in a manner relevant...