Johanna M Buschhaus
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Explore the profile of Johanna M Buschhaus including associated specialties, affiliations and a list of published articles.
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19
Citations
379
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Recent Articles
1.
Sinha S, Callow B, Farfel A, Roy S, Chen S, Masotti M, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39480488
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an...
2.
Augimeri G, Gonzalez M, Paoli A, Eido A, Choi Y, Burman B, et al.
JCI Insight
. 2023 Aug;
8(18).
PMID: 37607007
Patients with triple-negative breast cancer remain at risk for metastatic disease despite treatment. The acquisition of chemoresistance is a major cause of tumor relapse and death, but the mechanisms are...
3.
Humphries B, Zhang A, Buschhaus J, Bevoor A, Farfel A, Rajendran S, et al.
iScience
. 2023 May;
26(6):106788.
PMID: 37235049
Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells. In this...
4.
Sinha S, Callow B, Farfel A, Roy S, Chen S, Rajendran S, et al.
bioRxiv
. 2023 Mar;
PMID: 36993616
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We modeled these interactions with tumor-MSC co-cultures and used an...
5.
Buschhaus J, Rajendran S, Chen S, Wharram B, Bevoor A, Cutter A, et al.
Mol Cancer Res
. 2023 Feb;
21(5):458-471.
PMID: 36735350
Implications: This study reveals how MSCs reprogram metabolism of ER+ breast cancer cells and point to MCT4 as potential therapeutic target to overcome resistance to antiestrogen drugs.
6.
Hiraki H, Matera D, Wang W, Prabhu E, Zhang Z, Midekssa F, et al.
Acta Biomater
. 2022 Sep;
163:378-391.
PMID: 36179980
The peritumoral stroma is a complex 3D tissue that provides cells with myriad biophysical and biochemical cues. Histologic observations suggest that during metastatic spread of carcinomas, these cues influence transformed...
7.
Robison T, Solipuram M, Heist K, Amouzandeh G, Lee W, Humphries B, et al.
JCI Insight
. 2022 Aug;
7(19).
PMID: 35998053
Histopathology, the standard method to assess BM in hematologic malignancies such as myeloproliferative neoplasms (MPNs), suffers from notable limitations in both research and clinical settings. BM biopsies in patients fail...
8.
Buschhaus J, Rajendran S, Humphries B, Cutter A, Muniz A, Ciavattone N, et al.
Oncogene
. 2022 Jun;
41(29):3705-3718.
PMID: 35732800
Patients with estrogen receptor-positive (ER+) breast cancer, the most common subtype, remain at risk for lethal metastatic disease years after diagnosis. Recurrence arises partly because tumor cells in bone marrow...
9.
Humphries B, Aliabouzar M, Quesada C, Bevoor A, Ho K, Farfel A, et al.
Adv Healthc Mater
. 2022 Feb;
11(10):e2101672.
PMID: 35106975
Cancer cells continually sense and respond to mechanical cues from the extracellular matrix (ECM). Interaction with the ECM can alter intracellular signaling cascades, leading to changes in processes that promote...
10.
Buschhaus J, Humphries B, Eckley S, Robison T, Cutter A, Rajendran S, et al.
Oncogene
. 2020 Jul;
39(34):5649-5662.
PMID: 32678295
Estrogen receptor-positive (ER+) breast cancer can recur up to 20 years after initial diagnosis. Delayed recurrences arise from disseminated tumors cells (DTCs) in sites such as bone marrow that remain...