Kasper Harpsoe
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Explore the profile of Kasper Harpsoe including associated specialties, affiliations and a list of published articles.
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47
Citations
1115
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Recent Articles
21.
Zhang H, Nielsen A, Boesgaard M, Harpsoe K, Daly N, Xiong X, et al.
Eur J Med Chem
. 2018 Jul;
156:847-860.
PMID: 30055466
G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural product cyclic depsipeptides YM-254890 and FR900359 are...
22.
Peng Y, McCorvy J, Harpsoe K, Lansu K, Yuan S, Popov P, et al.
Cell
. 2018 Feb;
172(4):719-730.e14.
PMID: 29398112
Drugs frequently require interactions with multiple targets-via a process known as polypharmacology-to achieve their therapeutic actions. Currently, drugs targeting several serotonin receptors, including the 5-HT receptor, are useful for treating...
23.
Pandy-Szekeres G, Munk C, Tsonkov T, Mordalski S, Harpsoe K, Hauser A, et al.
Nucleic Acids Res
. 2017 Nov;
46(D1):D440-D446.
PMID: 29155946
G protein-coupled receptors are the most abundant mediators of both human signalling processes and therapeutic effects. Herein, we report GPCRome-wide homology models of unprecedented quality, and roughly 150 000 GPCR...
24.
Krall J, Hatt Jensen C, Bavo F, Falk-Petersen C, Haugaard A, Vogensen S, et al.
J Med Chem
. 2017 Oct;
60(21):9022-9039.
PMID: 29028338
γ-Hydroxybutyric acid (GHB) is a neuroactive substance with specific high-affinity binding sites. To facilitate target identification and ligand optimization, we herein report a comprehensive structure-affinity relationship study for novel ligands...
25.
Di Giglio M, Muttenthaler M, Harpsoe K, Liutkeviciute Z, Keov P, Eder T, et al.
Sci Rep
. 2017 Feb;
7:41002.
PMID: 28145450
Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored...
26.
Harpsoe K, Boesgaard M, Munk C, Brauner-Osborne H, Gloriam D
Bioinformatics
. 2016 Dec;
33(8):1116-1120.
PMID: 28011766
Motivation: Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of structural insight,...
27.
Isberg V, Mordalski S, Munk C, Rataj K, Harpsoe K, Hauser A, et al.
Nucleic Acids Res
. 2016 Dec;
45(5):2936.
PMID: 27923934
No abstract available.
28.
Shehata M, Nohr A, Lissa D, Bisig C, Isberg V, Andersen K, et al.
Sci Rep
. 2016 Nov;
6:36681.
PMID: 27830715
GPR139 is an orphan class A G protein-coupled receptor found mainly in the central nervous system. It has its highest expression levels in the hypothalamus and striatum, regions regulating metabolism...
29.
Xiong X, Zhang H, Underwood C, Harpsoe K, Gardella T, Woldike M, et al.
Nat Chem
. 2016 Oct;
8(11):1035-1041.
PMID: 27768111
G proteins are key mediators of G protein-coupled receptor signalling, which facilitates a plethora of important physiological processes. The cyclic depsipeptides YM-254890 and FR900359 are the only known specific inhibitors...
30.
Munk C, Harpsoe K, Hauser A, Isberg V, Gloriam D
Curr Opin Pharmacol
. 2016 Aug;
30:51-58.
PMID: 27475047
G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins, as well as drug targets. A recent boom in GPCR structural biology has provided detailed images of receptor...