Alexander S Hauser
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Explore the profile of Alexander S Hauser including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
2492
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Recent Articles
1.
Usher S, Toulme E, Florea R, Yatskevich S, Jao C, Dijkhof L, et al.
Sci Adv
. 2025 Mar;
11(11):eads6004.
PMID: 40085699
NALCN (sodium leak channel, nonselective) is vital for regulating electrical activity in neurons and other excitable cells, and mutations in the channel or its auxiliary proteins lead to severe neurodevelopmental...
2.
Lorente J, Sokolov A, Ferguson G, Schioth H, Hauser A, Gloriam D
Nat Rev Drug Discov
. 2025 Mar;
PMID: 40033110
G protein-coupled receptors (GPCRs) form one of the largest drug target families, reflecting their involvement in numerous pathophysiological processes. In this Review, we analyse drug discovery trends for the GPCR...
3.
Thompson M, Chidiac P, Jose P, Hauser A, Gorvin C
Crit Rev Clin Lab Sci
. 2025 Jan;
62(2):113-134.
PMID: 39743506
We present a series of three articles on the genetics and pharmacogenetics of G protein- coupled receptors (GPCR). In the first article, we discuss genetic variants of the G protein...
4.
Duong Nguyen T, Tanoli Z, Hassan S, Ozcan U, Caroli J, Kooistra A, et al.
Nucleic Acids Res
. 2024 Nov;
53(D1):D1486-D1497.
PMID: 39565203
Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with significant implications for personalized medicine. As researchers and healthcare professionals...
5.
Thompson M, Reiner-Link D, Berghella A, Rana B, Rovati G, Capra V, et al.
Crit Rev Clin Lab Sci
. 2024 Aug;
61(8):641-684.
PMID: 39119983
The field of pharmacogenetics, the investigation of the influence of one or more sequence variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline that takes a...
6.
Kizilkaya H, Sorensen K, Madsen J, Lindquist P, Douros J, Bork-Jensen J, et al.
Nat Metab
. 2024 Jun;
6(7):1268-1281.
PMID: 38871982
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1...
7.
Reiner-Link D, Madsen J, Gloriam D, Brauner-Osborne H, Hauser A
Br J Pharmacol
. 2024 May;
PMID: 38725357
Background And Purpose: The dopamine D receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S...
8.
Thompson M, Percy M, Cole D, Bichet D, Hauser A, Gorvin C
Crit Rev Clin Lab Sci
. 2024 Mar;
61(5):317-346.
PMID: 38497103
Genetic variations in the genes encoding G protein-coupled receptors (GPCRs) can disrupt receptor structure and function, which can result in human genetic diseases. Disease-causing mutations have been reported in at...
9.
Wright S, Motso A, Koutsilieri S, Beusch C, Sabatier P, Berghella A, et al.
Nat Commun
. 2023 Oct;
14(1):6243.
PMID: 37813859
G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step...
10.
Melchiorsen J, Sorensen K, Bork-Jensen J, Kizilkaya H, Gasbjerg L, Hauser A, et al.
J Clin Endocrinol Metab
. 2023 May;
108(11):2821-2833.
PMID: 37235780
Context: Lost glucagon-like peptide 1 receptor (GLP-1R) function affects human physiology. Objective: This work aimed to identify coding nonsynonymous GLP1R variants in Danish individuals to link their in vitro phenotypes...