Kasper Harpsoe
Overview
Explore the profile of Kasper Harpsoe including associated specialties, affiliations and a list of published articles.
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47
Citations
1115
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Recent Articles
11.
Nakamoto C, Goto Y, Tomizawa Y, Fukata Y, Fukata M, Harpsoe K, et al.
Mol Brain
. 2021 Dec;
14(1):173.
PMID: 34872607
Dopamine (DA) and norepinephrine (NE) are pivotal neuromodulators that regulate a broad range of brain functions, often in concert. Despite their physiological importance, untangling the relationship between DA and NE...
12.
Moo E, Harpsoe K, Hauser A, Masuho I, Brauner-Osborne H, Gloriam D, et al.
Cell Chem Biol
. 2021 Jul;
29(2):226-238.e4.
PMID: 34302750
G-protein-coupled receptors (GPCRs) represent the largest family of drug targets. Upon activation, GPCRs signal primarily via a diverse set of heterotrimeric G proteins. Most GPCRs can couple to several different...
13.
Falk-Petersen C, Rostrup F, Loffler R, Buchleithner S, Harpsoe K, Gloriam D, et al.
Mol Pharmacol
. 2021 May;
100(1):46-56.
PMID: 33990405
Delta selective compound 2 (DS2; 4-chloro--[2-(2-thienyl)imidazo[1,2-]pyridin-3-yl]benzamide) is one of the most widely used tools to study selective actions mediated by -subunit-containing GABA receptors. DS2 was discovered over 10 years ago,...
14.
Xu P, Huang S, Zhang H, Mao C, Zhou X, Cheng X, et al.
Nature
. 2021 Mar;
592(7854):469-473.
PMID: 33762731
Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter that activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5-HT, 5-HT, 5-HT and other 5-HT receptors are used to...
15.
Bartling C, Jensen T, Henry S, Colliander A, Sereikaite V, Wenzler M, et al.
J Am Chem Soc
. 2021 Jan;
143(2):891-901.
PMID: 33398998
There is an urgent need for novel therapeutic approaches to treat Alzheimer's disease (AD) with the ability to both alleviate the clinical symptoms and halt the progression of the disease....
16.
Boesgaard M, Harpsoe K, Malmberg M, Underwood C, Inoue A, Mathiesen J, et al.
J Biol Chem
. 2020 Aug;
295(40):13850-13861.
PMID: 32753482
Heterotrimeric G proteins are essential mediators of intracellular signaling of G protein-coupled receptors. The G subfamily consists of G, G, G, and G proteins, of which all but G are...
17.
Falk-Petersen C, Tsonkov T, Nielsen M, Harpsoe K, Bundgaard C, Frolund B, et al.
Sci Rep
. 2020 Jun;
10(1):10078.
PMID: 32572053
Brain GABA receptors are ionotropic receptors belonging to the class of Cys-loop receptors and are important drug targets for the treatment of anxiety and sleep disorders. By screening a compound...
18.
Giraudo A, Krall J, Bavo F, Nielsen B, Kongstad K, Rolando B, et al.
J Med Chem
. 2019 May;
62(12):5797-5809.
PMID: 31117514
Given the heterogeneity within the γ-aminobutyric acid (GABA) receptor and transporter families, a detailed insight into the pharmacology is still relatively sparse. To enable studies of the physiological roles governed...
19.
Krall J, Bavo F, Falk-Petersen C, Jensen C, Nielsen J, Tian Y, et al.
J Med Chem
. 2019 Feb;
62(5):2798-2813.
PMID: 30763084
Gabazine, a γ-aminobutyric acid type A (GABA) receptor antagonist, has previously been reported to inhibit the binding of [H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive...
20.
Malfacini D, Patt J, Annala S, Harpsoe K, Eryilmaz F, Reher R, et al.
J Biol Chem
. 2019 Feb;
294(15):5747-5758.
PMID: 30745359
Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family G...