Kristian Stromgaard
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Explore the profile of Kristian Stromgaard including associated specialties, affiliations and a list of published articles.
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152
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2202
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Recent Articles
1.
Nielsen A, Bartling C, Zarda A, De Sadeleer N, Neeser R, Schwaller P, et al.
Angew Chem Int Ed Engl
. 2025 Mar;
:e202500493.
PMID: 40052878
Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far not all cyclic peptides are cell permeable,...
2.
Fernandes E, Knudsen L, Kjaer A, Stromgaard K, Herth M
Bioorg Med Chem Lett
. 2025 Feb;
120:130118.
PMID: 39892469
The absence of universal and expedient labeling procedures hampers the widespread application of peptides as molecular tracers for positron emission tomography (PET). In this work, we have developed a proof-of-concept...
3.
Gangwar S, Yelshanskaya M, Aktolun M, Yen L, Newton T, Stromgaard K, et al.
Nat Commun
. 2024 Nov;
15(1):10257.
PMID: 39592599
Kainate receptors (KARs) are a subtype of ionotropic glutamate receptor (iGluR) channels, a superfamily of ligand-gated ion channels which mediate the majority of excitatory neurotransmission in the central nervous system....
4.
Nielsen J, Lauritsen J, Pedersen J, Nowak J, Bendtsen M, Kleijwegt G, et al.
NPJ Parkinsons Dis
. 2024 Jul;
10(1):139.
PMID: 39075088
α-Synuclein (α-syn) accumulates as insoluble amyloid but also forms soluble α-syn oligomers (αSOs), thought to be even more cytotoxic than fibrils. To detect and block the unwanted activities of these...
5.
Fruh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen L, Fernandez-Fernandez D, et al.
Sci Adv
. 2024 Jul;
10(28):eadk5462.
PMID: 38985877
Adherens junction-associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid...
6.
Rezi C, Aslanyan M, Diwan G, Cheng T, Chamlali M, Junger K, et al.
EMBO Rep
. 2024 Jun;
25(7):3040-3063.
PMID: 38849673
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the...
7.
Petersen J, Ludwig M, Juozaityte V, Ranea-Robles P, Svendsen C, Hwang E, et al.
Nature
. 2024 May;
629(8014):1133-1141.
PMID: 38750368
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel that is critical to many processes in the brain. Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity...
8.
Nielsen A, Bognar Z, Mothukuri G, Zarda A, Schuttel M, Merz M, et al.
Angew Chem Int Ed Engl
. 2024 Apr;
63(26):e202400350.
PMID: 38602024
Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for...
9.
Andersen I, Bidesi N, Shalgunov V, Jorgensen J, Gustavsson T, Stromgaard K, et al.
Nucl Med Biol
. 2024 Mar;
132-133:108905.
PMID: 38555651
DOTATATE is a somatostatin peptide analog used in the clinic to detect somatostatin receptors which are highly expressed on neuroendocrine tumors. Somatostatin receptors are found naturally in the intestines, pancreas,...
10.
Fadahunsi N, Petersen J, Metz S, Jakobsen A, Vad Mathiesen C, Silke Buch-Rasmussen A, et al.
Sci Adv
. 2024 Mar;
10(9):eadg2636.
PMID: 38427737
Human genome-wide association studies (GWAS) suggest a functional role for central glutamate receptor signaling and plasticity in body weight regulation. Here, we use UK Biobank GWAS summary statistics of body...