Hans Brauner-Osborne
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Explore the profile of Hans Brauner-Osborne including associated specialties, affiliations and a list of published articles.
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178
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3220
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Recent Articles
1.
Moo E, Moller T, Sorensen F, Inoue A, Brauner-Osborne H
FEBS J
. 2025 Jan;
PMID: 39756024
The glucagon-like peptide-1 receptor (GLP-1R) plays an important role in regulating insulin secretion and reducing body weight, making it a prominent target in the treatment of type 2 diabetes and...
2.
Du W, Rahman S, Barker E, Brauner-Osborne H, Mathiesen J, Ward D, et al.
Biochem Pharmacol
. 2024 Nov;
231:116619.
PMID: 39522703
The calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and small-molecule and peptide positive allosteric modulators (PAMs) of CaSR, so-called calcimimetics, are used in the treatment of hyperparathyroidism...
3.
Du W, Boisen I, Rahman S, Poulsen N, Mathiesen J, Blomberg Jensen M, et al.
J Clin Endocrinol Metab
. 2024 Oct;
PMID: 39413244
Context And Objectives: The human calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and most identified CASR variants are associated with hypercalcemic and hypocalcemic disorders. Here we characterized...
4.
Yeung H, Ramiro I, Andersen D, Koch T, Hamilton A, Bjorn-Yoshimoto W, et al.
Nat Commun
. 2024 Aug;
15(1):6408.
PMID: 39164229
Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor, and cardiovascular systems or cause tissue damage. The discovery that...
5.
Boisen I, Du W, Juul A, Brauner-Osborne H, Jensen A, Blomberg Jensen M
J Clin Endocrinol Metab
. 2024 Jun;
PMID: 38920275
Context And Objectives: To date, only four loss-of-function variants in the GNA11 gene encoding the G protein subunit α11 (Gα11) leading to familial hypocalciuric hypercalcemia 2 (FHH2) have been characterized....
6.
Reiner-Link D, Madsen J, Gloriam D, Brauner-Osborne H, Hauser A
Br J Pharmacol
. 2024 May;
PMID: 38725357
Background And Purpose: The dopamine D receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S...
7.
Ieremias L, Kaspersen M, Manandhar A, Schultz-Knudsen K, Vrettou C, Pokhrel R, et al.
J Med Chem
. 2024 Feb;
67(5):3542-3570.
PMID: 38381650
GPR84 is a putative medium-chain fatty acid receptor that is implicated in regulation of inflammation and fibrogenesis. Studies have indicated that GPR84 agonists may have therapeutic potential in diseases such...
8.
Alexander S, Christopoulos A, Davenport A, Kelly E, Mathie A, Peters J, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S23-S144.
PMID: 38123151
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
9.
Moller T, Moo E, Inoue A, Pedersen M, Brauner-Osborne H
Biochim Biophys Acta Mol Cell Res
. 2023 Sep;
1871(1):119584.
PMID: 37714305
G protein-coupled receptors (GPCRs) are seven transmembrane receptors that respond to external stimuli and undergo conformational changes to activate G proteins and modulate cellular processes leading to biological outcomes. To...
10.
Deng Y, Moo E, Inoue A, Brauner-Osborne H
FEBS Lett
. 2023 Apr;
597(11):1528-1540.
PMID: 37051832
GPR15 is a G protein-coupled receptor involved in immune disorders such as human immunodeficiency virus-induced enteropathy, multiple sclerosis, and colitis. Yet, the important endocytosis mechanism of GPR15 remained unclear. This...