Kasper Harpsoe
Overview
Explore the profile of Kasper Harpsoe including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
1115
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Recent Articles
1.
Chan C, Pottie E, Simon I, Rossebo A, Herth M, Harpsoe K, et al.
ACS Chem Neurosci
. 2025 Jan;
16(3):439-451.
PMID: 39836645
The serotonin 7 receptor (5-HTR) regulates various processes in the central nervous system, including mood, learning, and circadian rhythm control, among others. Receptor activation can lead to activation of the...
2.
Simon I, Bjorn-Yoshimoto W, Harpsoe K, Iliadis S, Svensson B, Jensen A, et al.
Trends Pharmacol Sci
. 2023 Nov;
44(12):978-990.
PMID: 37914598
Serotonin is a neurotransmitter regulating numerous physiological processes also modulated by drugs, for example, schizophrenia, depression, migraine, and obesity. However, these drugs typically have adverse effects caused by promiscuous binding...
3.
Pottie E, Poulie C, Simon I, Harpsoe K, DAndrea L, Komarov I, et al.
ACS Chem Neurosci
. 2023 Jul;
14(15):2727-2742.
PMID: 37474114
Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT) as their main pharmacological action. Despite their relevance, the molecular mechanisms underlying the psychedelic effects induced by...
4.
Caroli J, Mamyrbekov A, Harpsoe K, Gardizi S, Dorries L, Ghosh E, et al.
Nat Chem Biol
. 2023 Mar;
19(5):531-535.
PMID: 36973443
No abstract available.
5.
Marcher-Rorsted E, Nykodemova J, Harpsoe K, Jensen A, Kristensen J
ACS Med Chem Lett
. 2023 Mar;
14(3):319-325.
PMID: 36923922
The -benzylphenethylamines (NBOMes) are a class of ligands from which compounds with impressive selectivity for the serotonin 2A receptor (5-HTR) over the closely related serotonin 2C receptor (5-HTR) have emerged....
6.
Bartling C, Alexopoulou F, Kuschert S, Chin Y, Jia X, Sereikaite V, et al.
J Med Chem
. 2023 Feb;
66(4):3045-3057.
PMID: 36749163
Peptides targeting disease-relevant protein-protein interactions are an attractive class of therapeutics covering the otherwise undruggable space between small molecules and therapeutic proteins. However, peptides generally suffer from poor metabolic stability...
7.
Pallareti L, Rath T, Trapkov B, Tsonkov T, Nielsen A, Harpsoe K, et al.
Eur J Pharmacol
. 2023 Feb;
943:175553.
PMID: 36736525
The orphan G protein-coupled receptor GPR139 is predominantly expressed in the central nervous system and has attracted considerable interest as a therapeutic target. However, the biological role of this receptor...
8.
Poulie C, Pottie E, Simon I, Harpsoe K, DAndrea L, Komarov I, et al.
J Med Chem
. 2022 Sep;
65(18):12031-12043.
PMID: 36099411
The serotonin 2A receptor (5-HTR) is the mediator of the psychedelic effects of serotonergic psychedelics, which have shown promising results in clinical studies for several neuropsychiatric indications. The 5-HTR is...
9.
Huang S, Xu P, Shen D, Simon I, Mao C, Tan Y, et al.
Mol Cell
. 2022 Jun;
82(14):2681-2695.e6.
PMID: 35714614
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G, G or G proteins. The structural basis for G...
10.
Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, et al.
Cell Res
. 2021 Dec;
32(2):210-213.
PMID: 34916631
No abstract available.