Kanda Sangthongpitag
Overview
Explore the profile of Kanda Sangthongpitag including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
323
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Recent Articles
1.
Ng P, Foo K, Sim S, Wang G, Huang C, Tan L, et al.
Bioorg Med Chem
. 2021 Oct;
49:116437.
PMID: 34600239
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor...
2.
Kwiatkowski J, Liu B, Pang S, Ahmad N, Wang G, Poulsen A, et al.
J Med Chem
. 2020 Jan;
63(2):621-637.
PMID: 31910010
Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation...
3.
Huang C, Liew S, Lin G, Poulsen A, Ang M, Chia B, et al.
ACS Med Chem Lett
. 2019 Aug;
10(8):1240.
PMID: 31413812
[This corrects the article DOI: 10.1021/acsmedchemlett.9b00170.].
4.
Huang C, Liew S, Lin G, Poulsen A, Ang M, Chia B, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):978-984.
PMID: 31223458
SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent...
5.
Ho S, Wang W, Ng F, Wong Y, Poh Z, Tan S, et al.
Eur J Med Chem
. 2018 Aug;
157:610-621.
PMID: 30125722
Even though many GyrB and ParE inhibitors have been reported in the literature, few possess activity against Gram-negative bacteria. This is primarily due to limited permeability across Gram-negative bacterial membrane...
6.
Kwiatkowski J, Liu B, Tee D, Chen G, Ahmad N, Wong Y, et al.
J Med Chem
. 2018 Apr;
61(10):4386-4396.
PMID: 29688013
Protein kinase C iota (PKC-ι) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of a fragment library has identified several hits from which...
7.
Yang H, Chennamaneni L, Ho M, Ang S, Tan E, Jeyaraj D, et al.
J Med Chem
. 2018 Apr;
61(10):4348-4369.
PMID: 29683667
Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition of...
8.
Ho S, Alam J, Jeyaraj D, Wang W, Lin G, Ang S, et al.
J Med Chem
. 2017 Jul;
60(15):6678-6692.
PMID: 28671458
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising...
9.
Moreira W, Santhanakrishnan S, Ngan G, Low C, Sangthongpitag K, Poulsen A, et al.
Antimicrob Agents Chemother
. 2017 Feb;
61(5).
PMID: 28193668
is responsible for the greatest number of deaths worldwide due to a bacterial agent. We recently identified bortezomib (Velcade; compound 1) as a promising antituberculosis (anti-TB) compound. We showed that...
10.
Yeo C, Alexander I, Lin Z, Lim S, Aning O, Kumar R, et al.
Cell Rep
. 2016 Apr;
15(1):132-146.
PMID: 27052176
p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its...