Joshua S Kaminker
Overview
Explore the profile of Joshua S Kaminker including associated specialties, affiliations and a list of published articles.
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36
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5185
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Recent Articles
1.
Heredia J, Jung M, Balestrini A, Doerr J, Paler-Martinez A, Mozzarelli A, et al.
J Immunol
. 2023 Jul;
211(5):844-852.
PMID: 37477665
The lung is a barrier tissue with constant exposure to the inhaled environment. Therefore, innate immunity against particulates and pathogens is of critical importance to maintain tissue homeostasis. Although the...
2.
Orozco L, Owen L, Hofmann J, Stockwell A, Tao J, Haller S, et al.
Cell Genom
. 2023 Jun;
3(6):100302.
PMID: 37388919
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. To identify genes that could be targeted for treatment, we created a molecular atlas at...
3.
Deng L, Dourado M, Reese R, Huang K, Shields S, Stark K, et al.
Neuron
. 2023 Jun;
111(17):2642-2659.e13.
PMID: 37352856
Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is essential for the perception of pain. However, the mechanism by...
4.
Khan Z, Jung M, Crow M, Mohindra R, Maiya V, Kaminker J, et al.
Genome Med
. 2023 Jun;
15(1):45.
PMID: 37344884
Background: Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities....
5.
Jung M, Dourado M, Maksymetz J, Jacobson A, Laufer B, Baca M, et al.
Nat Commun
. 2023 Jan;
14(1):366.
PMID: 36690629
Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of DRGs are conducted in...
6.
Pandey S, Shen K, Lee S, Shen Y, Wang Y, Otero-Garcia M, et al.
Cell Rep
. 2022 Aug;
40(8):111189.
PMID: 36001972
Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte activation states would shed light on disease processes. We identify three distinct activation states of oligodendrocytes...
7.
Zhou J, Geng Y, Su T, Wang Q, Ren Y, Zhao J, et al.
Cell Rep
. 2022 Mar;
38(13):110557.
PMID: 35354047
Astrocytes play critical roles in brain development and disease, but the mechanisms that regulate astrocyte proliferation are poorly understood. We report that astrocyte proliferation is bi-directionally regulated by neuronal activity...
8.
Reeder J, Huang M, Kaminker J, Paulson J
Bioinformatics
. 2020 Sep;
37(9):1317-1318.
PMID: 32960962
Summary: We developed the MicrobiomeExplorer R package to facilitate the analysis and visualization of microbial communities. The MicrobiomeExplorer R package allows a user to perform typical microbiome analytic workflows and...
9.
Friedman B, Srinivasan K, Ayalon G, Meilandt W, Lin H, Huntley M, et al.
Cell Rep
. 2018 Jan;
22(3):832-847.
PMID: 29346778
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles...
10.
Chang M, Srinivasan K, Friedman B, Suto E, Modrusan Z, Lee W, et al.
J Exp Med
. 2017 Aug;
214(9):2611-2628.
PMID: 28778989
Loss-of-function mutations in cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusions and neuronal ceroid lipofuscinosis (NCL). There are no disease-modifying therapies for either FTD...