Brad A Friedman
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Explore the profile of Brad A Friedman including associated specialties, affiliations and a list of published articles.
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34
Citations
2202
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Recent Articles
1.
Kahn O, Dominguez S, Glock C, Hayne M, Vito S, Sengupta Ghosh A, et al.
Cell Rep
. 2025 Mar;
44(3):115382.
PMID: 40056413
Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein that provides structural support for axons and is released into the extracellular space following neuronal injury. While NfL has been extensively...
2.
Schauer S, Cho C, Novikova G, Roth G, Lee J, Sharma A, et al.
Alzheimers Dement
. 2024 Aug;
20(9):5861-5888.
PMID: 39090679
Introduction: Triggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease-modifying therapeutics for Alzheimer's disease. Clinically translatable pharmacodynamic (PD) biomarkers are needed to confirm drug...
3.
Etxeberria A, Shen Y, Vito S, Silverman S, Imperio J, Lalehzadeh G, et al.
J Neurosci
. 2024 Jun;
44(29.
PMID: 38830764
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist...
4.
Dominguez S, Laufer B, Sengupta Ghosh A, Li Q, Ruggeri G, Emani M, et al.
iScience
. 2023 Nov;
26(11):108362.
PMID: 37965143
Heterozygous mutations in the granulin () gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Polymorphisms in have been associated with disease risk in mutation carriers...
5.
Wang Y, Wu T, Tsai M, Rezzonico M, Abdel-Haleem A, Xie L, et al.
Elife
. 2023 Aug;
12.
PMID: 37555828
Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and...
6.
Byrnes A, Dominguez S, Yen C, Laufer B, Foreman O, Reichelt M, et al.
Mol Ther Nucleic Acids
. 2023 Jun;
32:773-793.
PMID: 37346977
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of neurological diseases. While ASOs have been effective in the clinic, improving productive ASO internalization into target cells remains...
7.
Dejanovic B, Wu T, Tsai M, Graykowski D, Gandham V, Rose C, et al.
Nat Aging
. 2023 Apr;
2(9):837-850.
PMID: 37118504
Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau synapse fractions with age...
8.
Pandey S, Shen K, Lee S, Shen Y, Wang Y, Otero-Garcia M, et al.
Cell Rep
. 2022 Aug;
40(8):111189.
PMID: 36001972
Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte activation states would shed light on disease processes. We identify three distinct activation states of oligodendrocytes...
9.
Lee S, Rezzonico M, Friedman B, Huntley M, Meilandt W, Pandey S, et al.
Cell Rep
. 2021 Dec;
37(13):110158.
PMID: 34965428
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in...
10.
Brendza R, Lin H, Stark K, Foreman O, Tao J, Pierce A, et al.
Neurobiol Dis
. 2021 Aug;
159:105494.
PMID: 34464706
The gene GPNMB is known to play roles in phagocytosis and tissue repair, and is upregulated in microglia in many mouse models of neurodegenerative disease as well as in human...