Zora Modrusan
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Explore the profile of Zora Modrusan including associated specialties, affiliations and a list of published articles.
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211
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20004
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Recent Articles
1.
Kapur P, Zhong H, Christie A, Xu H, Cai Q, Araj E, et al.
J Natl Cancer Inst
. 2025 Mar;
PMID: 40065697
The mechanisms underlying metastatic latency in renal cell carcinoma (RCC) remain poorly understood. This study evaluated two large independent cohorts for differences in tumor biology between patients who developed metastases...
2.
A comprehensive analysis framework for evaluating commercial single-cell RNA sequencing technologies
De Simone M, Hoover J, Lau J, Bennett H, Wu B, Chen C, et al.
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39675380
This study examined nine prominent commercially available single-cell RNA sequencing (scRNA-seq) kits across four technology groups. Each kit was characterized using peripheral blood mononuclear cells (PBMCs) from a single donor,...
3.
Cruz Tleugabulova M, Melo S, Wong A, Arlantico A, Liu M, Webster J, et al.
Nat Commun
. 2024 Nov;
15(1):9575.
PMID: 39505846
Macrophages are pleiotropic and diverse cells that populate all tissues of the body. Besides tissue-specific resident macrophages such as alveolar macrophages, Kupffer cells, and microglia, multiple organs harbor at least...
4.
Wu B, Bennett H, Ye X, Sridhar A, Eidenschenk C, Everett C, et al.
Nat Commun
. 2024 Oct;
15(1):9146.
PMID: 39443484
Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing...
5.
Perlman B, Burget N, Zhou Y, Schwartz G, Petrovic J, Modrusan Z, et al.
Nat Commun
. 2024 Sep;
15(1):8070.
PMID: 39277592
Recent advances in high-resolution mapping of spatial interactions among regulatory elements support the existence of complex topological assemblies of enhancers and promoters known as enhancer-promoter hubs or cliques. Yet, organization...
6.
Peng Y, Moffat J, DuPai C, Kofoed E, Skippington E, Modrusan Z, et al.
J Bacteriol
. 2024 Sep;
206(10):e0010224.
PMID: 39235234
Inosine 5'-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step in guanine biosynthesis and is conserved from humans to bacteria. We developed a series of potent inhibitors...
7.
Byrne A, Le D, Sereti K, Menon H, Vaidya S, Patel N, et al.
Nat Commun
. 2024 Aug;
15(1):6916.
PMID: 39134520
Single-cell RNA sequencing predominantly employs short-read sequencing to characterize cell types, states and dynamics; however, it is inadequate for comprehensive characterization of RNA isoforms. Long-read sequencing technologies enable single-cell RNA...
8.
Herault A, Mak J, de la Cruz-Chuh J, Dillon M, Ellerman D, Go M, et al.
Cancer Immunol Immunother
. 2024 Aug;
73(10):209.
PMID: 39112670
Background: Cancer immunotherapy approaches that elicit immune cell responses, including T and NK cells, have revolutionized the field of oncology. However, immunosuppressive mechanisms restrain immune cell activation within solid tumors...
9.
Perlman B, Burget N, Zhou Y, Schwartz G, Petrovic J, Modrusan Z, et al.
bioRxiv
. 2024 Jul;
PMID: 39005446
Recent advances in high-resolution mapping of spatial interactions among regulatory elements support the existence of complex topological assemblies of enhancers and promoters known as enhancer-promoter hubs or cliques. Yet, organization...
10.
Jasti J, Zhong H, Panwar V, Jarmale V, Miyata J, Carrillo D, et al.
ArXiv
. 2024 Jun;
PMID: 38855551
Background: Predictive biomarkers of treatment response are lacking for metastatic clearcell renal cell carcinoma (ccRCC), a tumor type that is treated with angiogenesis inhibitors, immune checkpoint inhibitors, mTOR inhibitors and...