David V Hansen
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Explore the profile of David V Hansen including associated specialties, affiliations and a list of published articles.
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36
Citations
4904
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Recent Articles
1.
Hsiao Y, Wallweber H, Alberstein R, Lin Z, Du C, Etxeberria A, et al.
Nat Commun
. 2024 Sep;
15(1):8382.
PMID: 39333507
We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune responses where antigen-specific clones with the...
2.
Etxeberria A, Shen Y, Vito S, Silverman S, Imperio J, Lalehzadeh G, et al.
J Neurosci
. 2024 Jun;
44(29.
PMID: 38830764
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist...
3.
Lee S, Rezzonico M, Friedman B, Huntley M, Meilandt W, Pandey S, et al.
Cell Rep
. 2021 Dec;
37(13):110158.
PMID: 34965428
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in...
4.
Lee S, Meilandt W, Xie L, Gandham V, Ngu H, Barck K, et al.
Neuron
. 2021 Mar;
109(8):1283-1301.e6.
PMID: 33675684
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2...
5.
Srinivasan K, Friedman B, Etxeberria A, Huntley M, van der Brug M, Foreman O, et al.
Cell Rep
. 2020 Jul;
31(13):107843.
PMID: 32610143
Damage-associated microglia (DAM) profiles observed in Alzheimer's disease (AD)-related mouse models reflect an activation state that could modulate AD risk or progression. To learn whether human AD microglia (HAM) display...
6.
Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al.
J Neurosci
. 2020 Jan;
40(9):1956-1974.
PMID: 31980586
is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking...
7.
Huntley M, Srinivasan K, Friedman B, Wang T, Yee A, Wang Y, et al.
J Neurosci
. 2019 Dec;
40(5):958-973.
PMID: 31831521
Cortical circuit activity is shaped by the parvalbumin (PV) and somatostatin (SST) interneurons that inhibit principal excitatory (EXC) neurons and the vasoactive intestinal peptide (VIP) interneurons that suppress activation of...
8.
Wu T, Dejanovic B, Gandham V, Gogineni A, Edmonds R, Schauer S, et al.
Cell Rep
. 2019 Aug;
28(8):2111-2123.e6.
PMID: 31433986
Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely...
9.
Rathore N, Ramani S, Pantua H, Payandeh J, Bhangale T, Wuster A, et al.
PLoS Genet
. 2018 Nov;
14(11):e1007427.
PMID: 30388101
Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia. We...
10.
Friedman B, Srinivasan K, Ayalon G, Meilandt W, Lin H, Huntley M, et al.
Cell Rep
. 2018 Jan;
22(3):832-847.
PMID: 29346778
Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles...