Joseph Rosenbluh
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Explore the profile of Joseph Rosenbluh including associated specialties, affiliations and a list of published articles.
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42
Citations
2481
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Recent Articles
1.
Hosseinpour M, Xi X, Liu L, Malaver-Ortega L, Perlaza-Jimenez L, Joo J, et al.
Nat Commun
. 2024 Dec;
15(1):10449.
PMID: 39617792
DNA methylation is an epigenetic mark that plays a critical role in regulating gene expression. DNA methyltransferase (DNMT) inhibitors, inhibit global DNA methylation and have been a key tool in...
2.
Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
Kulkarni A, Mohan V, Tang T, Post L, Chan Y, Manning M, et al.
EMBO Rep
. 2024 Aug;
25(9):3944-3969.
PMID: 39103676
The Hippo tumor suppressor pathway controls transcription by regulating nuclear abundance of YAP and TAZ, which activate transcription with the TEAD1-TEAD4 DNA-binding proteins. Recently, several small-molecule inhibitors of YAP and...
3.
Liu L, Neve M, Perlaza-Jimenez L, Xi X, Purcell J, Hawdon A, et al.
Nat Cell Biol
. 2024 Aug;
26(8):1359-1372.
PMID: 39095657
Circular RNA (circRNA) is covalently closed, single-stranded RNA produced by back-splicing. A few circRNAs have been implicated as functional; however, we lack understanding of pathways that are regulated by circRNAs....
4.
Wang L, Bitar M, Lu X, Jacquelin S, Nair S, Sivakumaran H, et al.
Mol Cancer
. 2024 May;
23(1):101.
PMID: 38745269
Background: Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs that were genetically linked to breast...
5.
Voon H, Hii L, Garvie A, Udugama M, Krug B, Russo C, et al.
Genome Biol
. 2023 Dec;
24(1):284.
PMID: 38066546
Background: Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These H3.3 point mutations affect many chromatin modifications but...
6.
Ghamsari R, Rosenbluh J, Menon A, Lovell N, Alinejad-Rokny H
Cancers (Basel)
. 2023 Jul;
15(14).
PMID: 37509229
Higher eukaryotic enhancers, as a major class of regulatory elements, play a crucial role in the regulation of gene expression. Over the last decade, the development of sequencing technologies has...
7.
Sun C, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, et al.
Cancer Cell
. 2023 Mar;
41(4):660-677.e7.
PMID: 37001527
Pediatric solid and central nervous system tumors are the leading cause of cancer-related death among children. Identifying new targeted therapies necessitates the use of pediatric cancer models that faithfully recapitulate...
8.
Tuano N, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega L, et al.
Genome Biol
. 2023 Mar;
24(1):59.
PMID: 36991492
Background: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk...
9.
Dowty J, Yu C, Hosseinpour M, Joo J, Wong E, Nguyen-Dumont T, et al.
Fam Cancer
. 2023 Jan;
22(3):313-317.
PMID: 36708485
DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part of the familial risk for cancer. We...
10.
Malaver-Ortega L, Rosenbluh J
Methods Mol Biol
. 2022 Jun;
2495:91-97.
PMID: 35696029
The ability of modifying the genome of multiple species, precisely and without or minimal off-targeted effects, have opened numerous opportunities for the biotechnology industry. In this chapter, we describe an...