Aviad Tsherniak
Overview
Explore the profile of Aviad Tsherniak including associated specialties, affiliations and a list of published articles.
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Articles
68
Citations
11136
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Recent Articles
1.
Tothova Z, Krill-Burger J, Popova K, Landers C, Sievers Q, Yudovich D, et al.
Cell Stem Cell
. 2024 Sep;
31(10):1548-1549.
PMID: 39321798
No abstract available.
2.
Krill-Burger J, Dempster J, Borah A, Paolella B, Root D, Golub T, et al.
Genome Biol
. 2023 Aug;
24(1):192.
PMID: 37612728
Background: Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer Dependency Map, to identify gene dependencies-genes...
3.
De Matos Simoes R, Shirasaki R, Downey-Kopyscinski S, Matthews G, Barwick B, Gupta V, et al.
Nat Cancer
. 2023 May;
4(5):754-773.
PMID: 37237081
Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic...
4.
Gannon H, Zou T, Kiessling M, Gao G, Cai D, Choi P, et al.
Nat Commun
. 2022 Apr;
13(1):1894.
PMID: 35365656
No abstract available.
5.
Pan J, Kwon J, Talamas J, Borah A, Vazquez F, Boehm J, et al.
Cell Syst
. 2022 Jan;
13(4):286-303.e10.
PMID: 35085500
In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation...
6.
Dempster J, Boyle I, Vazquez F, Root D, Boehm J, Hahn W, et al.
Genome Biol
. 2021 Dec;
22(1):343.
PMID: 34930405
CRISPR loss of function screens are powerful tools to interrogate biology but exhibit a number of biases and artifacts that can confound the results. Here, we introduce Chronos, an algorithm...
7.
Neggers J, Paolella B, Asfaw A, Rothberg M, Skipper T, Yang A, et al.
Cell Rep
. 2021 Jul;
36(2):109367.
PMID: 34260938
No abstract available.
8.
Sheffer M, Lowry E, Beelen N, Borah M, Amara S, Mader C, et al.
Nat Genet
. 2021 Jul;
53(8):1196-1206.
PMID: 34253920
To systematically define molecular features in human tumor cells that determine their degree of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness of hundreds...
9.
Dharia N, Kugener G, Guenther L, Malone C, Durbin A, Hong A, et al.
Nat Genet
. 2021 Mar;
53(4):529-538.
PMID: 33753930
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known...
10.
Pacini C, Dempster J, Boyle I, Goncalves E, Najgebauer H, Karakoc E, et al.
Nat Commun
. 2021 Mar;
12(1):1661.
PMID: 33712601
CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across large panels of cell lines to identify new therapeutic targets for precision cancer therapy. Integrating the datasets resulting from...