Joseph K Hexum
Overview
Explore the profile of Joseph K Hexum including associated specialties, affiliations and a list of published articles.
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9
Citations
276
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0
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Recent Articles
1.
Kumar R, Santa Chalarca C, Bockman M, Van Bruggen C, Grimme C, Dalal R, et al.
Chem Rev
. 2021 May;
121(18):11527-11652.
PMID: 33939409
The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising. The therapeutic potential of...
2.
Ingle N, Hexum J, Reineke T
Biomacromolecules
. 2020 Mar;
21(4):1379-1392.
PMID: 32118406
The improvement of nonviral gene therapies relies to a large extent on understanding many fundamental physical and biological properties of these systems. This includes interactions of synthetic delivery systems with...
3.
Van Bruggen C, Hexum J, Tan Z, Dalal R, Reineke T
Acc Chem Res
. 2019 Apr;
52(5):1347-1358.
PMID: 30993967
The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals. Most gene therapies currently rely...
4.
Phillips H, Tolstyka Z, Hall B, Hexum J, Hackett P, Reineke T
Biomacromolecules
. 2019 Mar;
20(4):1530-1544.
PMID: 30919629
Genome editing therapies hold great promise for the cure of monogenic and other diseases; however, the application of nonviral gene delivery methods is limited by both a lack of fundamental...
5.
Kerr J, Robison P, Shi G, Bogush A, Kempema A, Hexum J, et al.
Nat Commun
. 2015 Oct;
6:8526.
PMID: 26446751
In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca(2+) signalling in healthy muscle, but in...
6.
Kempema A, Widen J, Hexum J, Andrews T, Wang D, Rathe S, et al.
Bioorg Med Chem
. 2015 Jun;
23(15):4737-4745.
PMID: 26088334
Parthenolide (PTL) is a sesquiterpene lactone natural product with anti-proliferative activity to cancer cells. Selective eradication of leukemic stem cells (LSCs) over healthy hematopoietic stem cells (HSCs) by PTL has...
7.
Hexum J, Becker C, Kempema A, Ohlfest J, Largaespada D, Harki D
Bioorg Med Chem Lett
. 2015 May;
25(12):2493-5.
PMID: 25978958
LC-1 (also known as DMAPT or dimethylamino-parthenolide), a prodrug of parthenolide, was tested for anti-proliferative activity against glioma. LC-1 was found to have low micromolar cytotoxic activity against three glioma...
8.
Wen B, Hexum J, Widen J, Harki D, Brummond K
Org Lett
. 2013 May;
15(11):2644-7.
PMID: 23662902
Syntheses of two 6,12-guaianolide analogs are reported within. The scope of the tandem allylboration/lactonization chemistry is expanded to provide a functionalized allene-yne-containing α-methylene butyrolactone that undergoes a Rh(I)-catalyzed cyclocarbonylation reaction...
9.
Hexum J, Tello-Aburto R, Struntz N, Harned A, Harki D
ACS Med Chem Lett
. 2012 Aug;
3(6):459-464.
PMID: 22866208
A series of structurally simplified cryptocaryone analogues were synthesized by a facile Pd-catalyzed acetoxylation of alkyne-tethered cyclohexadienones and evaluated as inhibitors of NF-κB signaling. Compounds 10 and 11 were found...