Craig Van Bruggen
Overview
Explore the profile of Craig Van Bruggen including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
119
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0
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Recent Articles
1.
Roy P, Kreofsky N, Brown M, Van Bruggen C, Reineke T
JACS Au
. 2023 Jul;
3(7):1876-1889.
PMID: 37502160
Quinine is a promising natural product building block for polymer-based nucleic acid delivery vehicles as its structure enables DNA binding through both intercalation and electrostatic interactions. However, studies exploring the...
2.
Kumar R, Santa Chalarca C, Bockman M, Van Bruggen C, Grimme C, Dalal R, et al.
Chem Rev
. 2021 May;
121(18):11527-11652.
PMID: 33939409
The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising. The therapeutic potential of...
3.
Van Bruggen C, Punihaole D, Keith A, Schmitz A, Tolar J, Frontiera R, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(52):32919-32928.
PMID: 33318196
Polymeric vehicles that efficiently package and controllably release nucleic acids enable the development of safer and more efficacious strategies in genetic and polynucleotide therapies. Developing delivery platforms that endogenously monitor...
4.
Van Bruggen C, Hexum J, Tan Z, Dalal R, Reineke T
Acc Chem Res
. 2019 Apr;
52(5):1347-1358.
PMID: 30993967
The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals. Most gene therapies currently rely...
5.
Punihaole D, Workman R, Upadhyay S, Van Bruggen C, Schmitz A, Reineke T, et al.
J Phys Chem B
. 2018 Oct;
122(43):9840-9851.
PMID: 30336027
Quinine's ability to bind DNA and potentially inhibit transcription and translation has been examined as a mode of action for its antimalarial activity. UV absorption and fluorescence-based studies have lacked...