Matthew R Bockman
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Explore the profile of Matthew R Bockman including associated specialties, affiliations and a list of published articles.
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7
Citations
123
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Recent Articles
1.
Liu Q, Engelhart C, Wallach J, Tiwari D, Ge P, Manna A, et al.
J Med Chem
. 2025 Jan;
68(3):3065-3087.
PMID: 39823202
The antibacterial agent Bio-AMS is metabolized in vivo through hydrolysis of the central acyl-sulfamide linker leading to high clearance and release of a moderately cytotoxic metabolite . Herein, we disclose...
2.
Ohnsorg M, Prendergast P, Robinson L, Bockman M, Bates F, Reineke T
ACS Macro Lett
. 2022 May;
10(3):375-381.
PMID: 35549060
Bottlebrush polymers have great potential as vehicles to noncovalently sequester, stabilize, and deliver hydrophobic small molecule actives. To this end, we synthesized a poly(-isopropylacrylamide--,-dimethylacrylamide) bottlebrush copolymer using ring-opening metathesis polymerization...
3.
Kumar R, Santa Chalarca C, Bockman M, Van Bruggen C, Grimme C, Dalal R, et al.
Chem Rev
. 2021 May;
121(18):11527-11652.
PMID: 33939409
The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising. The therapeutic potential of...
4.
Bockman M, Mishra N, Aldrich C
Curr Med Chem
. 2019 Jan;
27(25):4194-4232.
PMID: 30663561
Mycobacterium tuberculosis, responsible for Tuberculosis (TB), remains the leading cause of mortality among infectious diseases worldwide from a single infectious agent, with an estimated 1.7 million deaths in 2016. Biotin...
5.
Bockman M, Engelhart C, Cramer J, Howe M, Mishra N, Zimmerman M, et al.
ACS Infect Dis
. 2019 Jan;
5(4):598-617.
PMID: 30652474
The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of ( S)-(-)-acidomycin are described. Acidomycin possesses promising antitubercular activity against a series of...
6.
Bockman M, Engelhart C, Dawadi S, Larson P, Tiwari D, Ferguson D, et al.
ACS Infect Dis
. 2018 Apr;
4(7):1102-1113.
PMID: 29663798
5'-[ N-(d-biotinoyl)sulfamoyl]amino-5'-deoxyadenosine (Bio-AMS, 1) possesses selective activity against Mycobacterium tuberculosis ( Mtb) and arrests fatty acid and lipid biosynthesis through inhibition of the Mycobacterium tuberculosis biotin protein ligase ( MtBPL)....
7.
Bollivar D, Bernardoni B, Bockman M, Miller B, Russell D, Delesalle V, et al.
Genome Announc
. 2016 May;
4(3).
PMID: 27231352
Five bacteriophages that infect the Rhodobacter capsulatus strain YW1 were isolated from stream water near Bloomington, Illinois, USA. Two distinct genome types are represented in the newly isolated bacteriophages. These...
8.
Bockman M, Kalinda A, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, et al.
J Med Chem
. 2015 Aug;
58(18):7349-7369.
PMID: 26299766
Mycobacterium tuberculosis (Mtb), responsible for both latent and symptomatic tuberculosis (TB), remains the second leading cause of mortality among infectious diseases worldwide. Mycobacterial biotin protein ligase (MtBPL) is an essential...