Johan Wannberg
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Explore the profile of Johan Wannberg including associated specialties, affiliations and a list of published articles.
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17
Citations
118
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Recent Articles
1.
Akaberi D, Pourghasemi Lati M, Krambrich J, Berger J, Neilsen G, Strandback E, et al.
Antimicrob Agents Chemother
. 2024 Aug;
68(10):e0090924.
PMID: 39194208
screening of large compound libraries with automated high-throughput screening is expensive and time-consuming and requires dedicated infrastructures. Conversely, the selection of DNA-encoded chemical libraries (DECLs) can be rapidly performed with...
2.
Wannberg J, Gising J, Henriksson M, Vo D, Savmarker J, Sallander J, et al.
Eur J Med Chem
. 2024 Jan;
265:116122.
PMID: 38199164
Two series of N-(heteroaryl)thiophene sulfonamides, encompassing either a methylene imidazole group or a tert-butylimidazolylacetyl group in the meta position of the benzene ring, have been synthesized. An ATR selective ligand...
3.
Bonagas N, Gustafsson N, Henriksson M, Marttila P, Gustafsson R, Wiita E, et al.
Nat Cancer
. 2022 Mar;
3(2):156-172.
PMID: 35228749
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In...
4.
Wannberg J, Gising J, Lindman J, Salander J, Gutierrez-de-Teran H, Ablahad H, et al.
Bioorg Med Chem
. 2020 Dec;
29:115859.
PMID: 33309749
A series of meta-substituted acetophenone derivatives, encompassing N-(alkyloxycarbonyl)thiophene sulfonamide fragments have been synthesized. Several selective AT2 receptor ligands were identified, among those a tert-butylimidazole derivative (20) with a K of...
5.
Larsson K, Steinmetz J, Bergqvist F, Arefin S, Spahiu L, Wannberg J, et al.
Br J Pharmacol
. 2019 Aug;
176(24):4625-4638.
PMID: 31404942
Background And Purpose: Microsomal PGE synthase-1 (mPGES-1), the inducible synthase that catalyses the terminal step in PGE biosynthesis, is of high interest as therapeutic target to treat inflammation. Inhibition of...
6.
Isaksson R, Lindman J, Wannberg J, Sallander J, Backlund M, Baraldi D, et al.
ChemistryOpen
. 2019 Jan;
8(1):114-125.
PMID: 30697513
We here report on our continued studies of ligands binding to the promising drug target angiotensin II type 2 receptor (ATR). Two series of compounds were synthesized and investigated. The...
7.
Wannberg J, Isaksson R, Bremberg U, Backlund M, Savmarker J, Hallberg M, et al.
Bioorg Med Chem Lett
. 2017 Dec;
28(3):519-522.
PMID: 29279275
A series of ATR ligands have been synthesized applying a quick, simple, and safe transesterification-type reaction whereby the sulfonyl carbamate alkyl tail of the selective ATR antagonist C38 was varied....
8.
Leclerc P, Idborg H, Spahiu L, Larsson C, Nekhotiaeva N, Wannberg J, et al.
Prostaglandins Other Lipid Mediat
. 2013 Sep;
107:26-34.
PMID: 24045148
Microsomal prostaglandin E synthase-1 (mPGES-1) inhibition has been suggested as an alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. We characterized a selective inhibitor of mPGES-1...
9.
Wannberg J, Wallinder C, Unlusoy M, Skold C, Larhed M
J Org Chem
. 2013 Mar;
78(8):4184-9.
PMID: 23477584
A convenient procedure for converting aryl alcohols to aryl fluorides via aryl nonafluorobutylsulfonates (ArONf) is presented. Moderate to good one-pot, two-step yields were achieved by this nonaflation and microwave-assisted, palladium-catalyzed...
10.
Spahiu L, Stenberg P, Larsson C, Wannberg J, Alterman M, Kull B, et al.
Assay Drug Dev Technol
. 2011 May;
9(5):487-95.
PMID: 21561373
Microsomal prostaglandin E(2) synthase-1 (MPGES1) catalyzes the formation of prostaglandin E(2) from the endoperoxide prostaglandin H(2). MPGES1 expression is induced in inflammatory diseases, and this enzyme is regarded as a...