Jiaxiong Lu
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Explore the profile of Jiaxiong Lu including associated specialties, affiliations and a list of published articles.
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22
Citations
195
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Recent Articles
1.
Ullah E, Lin S, Lu J, Bender C, Webster A, Malka S, et al.
JAMA Ophthalmol
. 2024 Sep;
142(11):1081-1086.
PMID: 39325468
Importance: Inherited retinal dystrophies (IRDs) present a challenge in clinical diagnostics due to their pronounced genetic heterogeneity. Despite advances in next-generation sequencing (NGS) technologies, a substantial portion of the genetic...
2.
Zuo Z, Cheng X, Ferdous S, Shao J, Li J, Bao Y, et al.
Nat Commun
. 2024 Aug;
15(1):6792.
PMID: 39117640
The development of the retina is under tight temporal and spatial control. To gain insights into the molecular basis of this process, we generate a single-nuclei dual-omic atlas of the...
3.
Xie Z, Zhang T, Kim S, Lu J, Zhang W, Lin C, et al.
PLoS Genet
. 2024 May;
20(5):e1011273.
PMID: 38728357
Existing imaging genetics studies have been mostly limited in scope by using imaging-derived phenotypes defined by human experts. Here, leveraging new breakthroughs in self-supervised deep representation learning, we propose a...
4.
Li J, Wang J, Ibarra I, Cheng X, Luecken M, Lu J, et al.
Res Sq
. 2023 Nov;
PMID: 38014002
Single-cell sequencing has revolutionized the scale and resolution of molecular profiling of tissues and organs. Here, we present an integrated multimodal reference atlas of the most accessible portion of the...
5.
Wang J, Cheng X, Liang Q, Owen L, Lu J, Zheng Y, et al.
Genome Biol
. 2023 Nov;
24(1):269.
PMID: 38012720
Background: Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and...
6.
Lu J, Zheng K, Bertrand R, Quinlan J, Ferdous S, Srinivasan T, et al.
Exp Eye Res
. 2023 Jul;
234:109596.
PMID: 37479075
Previous reports have demonstrated that defects in the spliceosome-associated protein CWC27 can lead to the degeneration of retinal cells in Cwc27 mutant mouse models. However, it is unknown whether gene...
7.
Qian X, Srinivasan T, He J, Lu J, Jin Y, Gu H, et al.
Dis Model Mech
. 2023 Jul;
16(7).
PMID: 37466006
Increasing evidence has supported the role of ceramide as a mediator of photoreceptor dysfunction or cell death in ceramide accumulation and deficiency contexts. TLCD3B, a non-canonical ceramide synthase, was previously...
8.
Lu J, Xiong K, Qian X, Choi J, Shim Y, Burnett J, et al.
Sci Rep
. 2022 Apr;
12(1):5575.
PMID: 35368022
SPATA7, an early onset LCA3 retinal disease gene, encodes a putative scaffold protein that is essential for the proper assembly of the connecting cilium (CC) complex in photoreceptors. Previous studies...
9.
Qian X, Liu H, Fu S, Lu J, Hung Y, Turner C, et al.
Invest Ophthalmol Vis Sci
. 2022 Mar;
63(3):11.
PMID: 35275174
Purpose: The purpose of this study was to assess the therapeutic efficacy of rAAV8-hGRK1-Tlcd3b in a Tlcd3b-/- mouse model of retinal generation and validate TLCD3B's role as a ceramide synthase...
10.
Li H, Yu Y, Zhao Y, Wu D, Yu X, Lu J, et al.
Cancer Lett
. 2019 May;
457:129-141.
PMID: 31100410
Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of...