Jean-Yves Winum
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Explore the profile of Jean-Yves Winum including associated specialties, affiliations and a list of published articles.
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154
Citations
2065
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Recent Articles
1.
Clement S, Richeter S, Winum J
ChemMedChem
. 2025 Jan;
:e202400893.
PMID: 39807074
Tumor-associated human carbonic anhydrases (hCAs), particularly isoforms hCA IX and hCA XII, are overexpressed in hypoxic regions of solid tumors and play a crucial role in regulating pH homeostasis, promoting...
2.
Serhouni A, Calzaferri F, Bessina Y, van der Lee A, Arimondo P, Louet M, et al.
Bioorg Med Chem
. 2024 Dec;
118():117988.
PMID: 39689413
Flavonoid derivatives are natural product analogues that have shown great interest for therapeutic applications as modulators of DNA methylation. In this article we report new synthesis pathways to access ten...
3.
Mustafa M, Rashed M, Winum J
Expert Opin Drug Discov
. 2024 Dec;
20(1):103-121.
PMID: 39670847
Introduction: Hypoxia is a key feature of solid tumors, associated with aggressive behaviors such as radiation and chemotherapy resistance, increased metastasis, and poor prognosis. Hypoxia-inducible factors (HIFs) are essential transcription...
4.
Esposito D, Monti S, Supuran C, Winum J, De Simone G, Alterio V
Int J Biol Macromol
. 2024 Oct;
282(Pt 2):136873.
PMID: 39454912
Boronic acids are an interesting but still poorly studied class of carbonic anhydrase inhibitors. Previous investigations proved that derivatives incorporating aromatic, arylalkyl, and arylalkenyl moieties are low micromolar to millimolar...
5.
Giovannuzzi S, Nikitjuka A, Angeli A, Smietana M, Massardi M, Turati M, et al.
J Med Chem
. 2024 Oct;
67(20):18221-18234.
PMID: 39378331
The benzoxaborinine scaffold, a homologue of benzoxaborole with an additional carbon atom in the boracycle, shows significant potential in developing new therapeutic agents. This study reports the synthesis, inhibition assays...
6.
Clement S, Winum J
Expert Opin Ther Pat
. 2024 Mar;
34(6):401-414.
PMID: 38439633
Introduction: Antibacterial photodynamic therapy presents a promising alternative to antibiotics, with potential against multidrug-resistant bacteria, offering broad-spectrum action, reduced resistance risk, and improved tissue selectivity. Areas Covered: This manuscript reviews...
7.
Giovannuzzi S, Nikitjuka A, Pereira Resende B, Smietana M, Nocentini A, Supuran C, et al.
Bioorg Chem
. 2023 Nov;
143:106976.
PMID: 38000350
Over the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and...
8.
Merabti A, Richeter S, Supuran C, Clement S, Winum J
Expert Opin Ther Targets
. 2023 Sep;
27(9):817-826.
PMID: 37668158
Introduction: Photodynamic therapy (PDT) is a reactive oxygen species (ROS)-dependent treatment modality which has emerged as an alternative cancer therapy strategy. However, in solid tumors, the therapeutic efficacy of PDT...
9.
Nocentini A, Bonardi A, Bazzicalupi C, Alterio V, Esposito D, Monti S, et al.
J Med Chem
. 2023 Jun;
66(12):8118-8129.
PMID: 37283561
Benzoxaborole is currently a scaffold of great relevance in medicinal chemistry. In 2016, it was reported to be a new and valuable chemotype for designing carbonic anhydrase (CA) inhibitors. Herein,...
10.
Mustafa M, Winum J
Expert Opin Drug Discov
. 2022 Feb;
17(5):501-512.
PMID: 35193437
Introduction: Sulfur-containing functional groups are privileged motifs that occur in various pharmacologically effective substances and several natural products. Various functionalities are found with a sulfur atom at diverse oxidation states,...