Alessio Innocenti
Overview
Explore the profile of Alessio Innocenti including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
1557
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Recent Articles
1.
Lucarini L, Magnelli L, Schiavone N, Crisci A, Innocenti A, Puccetti L, et al.
J Enzyme Inhib Med Chem
. 2017 Dec;
33(1):234-240.
PMID: 29251173
Carbonic anhydrase (CA, EC 4.2.1.1) IX is regarded as a tumour hypoxia marker and CA inhibitors have been proposed as a new class of antitumor agents, with one such agent...
2.
Zoccola D, Innocenti A, Bertucci A, Tambutte E, Supuran C, Tambutte S
Mar Drugs
. 2016 Jun;
14(6).
PMID: 27271641
Global change is a major threat to the oceans, as it implies temperature increase and acidification. Ocean acidification (OA) involving decreasing pH and changes in seawater carbonate chemistry challenges the...
3.
Akurathi V, Dubois L, Celen S, Lieuwes N, Chitneni S, Cleynhens B, et al.
Eur J Med Chem
. 2014 Jan;
71:374-84.
PMID: 24378650
In vivo visualization of tumor hypoxia related markers, such as the endogenous transmembrane protein CA IX may lead to novel therapeutic and diagnostic applications in the management of solid tumors....
4.
Rummer J, McKenzie D, Innocenti A, Supuran C, Brauner C
Science
. 2013 Jun;
340(6138):1327-9.
PMID: 23766325
The Root effect is a pH-dependent reduction in hemoglobin-O2 carrying capacity. Specific to ray-finned fishes, the Root effect has been ascribed specialized roles in retinal oxygenation and swimbladder inflation. We...
5.
Bellissima F, Carta F, Innocenti A, Scozzafava A, Baglioni P, Supuran C, et al.
Eur Phys J E Soft Matter
. 2013 May;
36(5):48.
PMID: 23677447
Gold nanoparticles (AuNPs) have gained attention for their potential and application in different fields, e.g. nanomedicine. This study explores the surface functionalization of AuNP with inhibitors of carbonic anhydrases (CAs,...
6.
Sechi M, Innocenti A, Pala N, Rogolino D, Carcelli M, Scozzafava A, et al.
Bioorg Med Chem Lett
. 2012 Aug;
22(18):5801-6.
PMID: 22901388
The members of a focused series of carboxylic acids and of their derivatives (esters, amides and metal complexes) have been investigated as inhibitors of the main cytosolic/transmembrane carbonic anhydrase isoforms,...
7.
Reich R, Hoffman A, Veerendhar A, Maresca A, Innocenti A, Supuran C, et al.
J Med Chem
. 2012 Aug;
55(17):7875-82.
PMID: 22894736
Carbamoylphosphonates (CPOs) have been identified as inhibitors of matrix metalloproteinases (MMPs) and as orally active, bioavailable, and safe antimetastatic agents. In this article, we focus on the direct antitumor activity...
8.
Lee H, Bae T, Lee J, Kim D, Oh Y, Jang Y, et al.
BMC Syst Biol
. 2012 Jul;
6:80.
PMID: 22748168
Background: The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new...
9.
Moeker J, Teruya K, Rossit S, Wilkinson B, Lopez M, Bornaghi L, et al.
Bioorg Med Chem
. 2012 Feb;
20(7):2392-404.
PMID: 22370338
A library of 32 novel glycoconjugate thiourea-bridged benzene sulfonamides have been synthesized from the reaction of glycosyl isothiocyanates with a panel of simple benzene sulfonamides comprising either a free amine...
10.
Can D, Spingler B, Schmutz P, Mendes F, Raposinho P, Fernandes C, et al.
Angew Chem Int Ed Engl
. 2012 Feb;
51(14):3354-7.
PMID: 22344779
Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for...