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Giuseppina De Simone

Explore the profile of Giuseppina De Simone including associated specialties, affiliations and a list of published articles. Areas
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Articles 143
Citations 2588
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Recent Articles
1.
Amiranda S, Succoio M, Anzilotti S, Cuomo O, Petrozziello T, Tedeschi V, et al.
Heliyon . 2025 Mar; 11(4):e42457. PMID: 40028587
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated...
2.
La Rocca U, Ricci R, Piciocchi A, Barberi W, Oldani E, Dominietto A, et al.
Blood Transfus . 2025 Feb; PMID: 39949023
Background: Antibodies directed against donor-specific HLA allele(s)/antigen(s) (DSAs) represent a known risk factor for hematopoietic stem cell transplantation (HSCT) engraftment. Still, the overall management needs to be standardized. Material And...
3.
Paloukopoulou C, Ntagli O, Gherardi L, Dourdouni V, Filippou G, Alterio V, et al.
Arch Pharm (Weinheim) . 2024 Dec; 358(1):e2400823. PMID: 39711099
In this study, four depsides were isolated from Origanum dictamnus L. and Satureja pilosa Velen. medicinal plants and their structures were assessed by means of one-dimensional (1D)- and two-dimensional (2D)-nuclear...
4.
DAmbrosio K, Di Fiore A, Alterio V, Langella E, Monti S, Supuran C, et al.
Chem Rev . 2024 Dec; 125(1):150-222. PMID: 39700306
Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the hydration of CO to bicarbonate and a proton. Currently, 15 isoforms have been identified, of which only 12 are...
5.
Esposito D, Monti S, Supuran C, Winum J, De Simone G, Alterio V
Int J Biol Macromol . 2024 Oct; 282(Pt 2):136873. PMID: 39454912
Boronic acids are an interesting but still poorly studied class of carbonic anhydrase inhibitors. Previous investigations proved that derivatives incorporating aromatic, arylalkyl, and arylalkenyl moieties are low micromolar to millimolar...
6.
Vivenzio V, Esposito D, Monti S, De Simone G
Enzymes . 2024 Sep; 55:31-63. PMID: 39222995
Carbonic anhydrases belonging to the α-class are widely distributed in bacterial species. These enzymes have been isolated from bacteria with completely different characteristics including both Gram-negative and Gram-positive strains. α-CAs...
7.
De Simone G, Supuran C
Expert Opin Ther Pat . 2024 May; 34(7):525-527. PMID: 38721921
No abstract available.
8.
Rafii H, Volt F, Bierings M, Dalle J, Ayas M, Rihani R, et al.
Transplant Cell Ther . 2024 Mar; 30(5):532.e1-532.e16. PMID: 38452872
Hematopoietic cell transplantation (HCT) remains the sole available curative treatment for Fanconi anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) HCT. This study aimed to describe...
9.
Angeli A, Micheli L, Turnaturi R, Pasquinucci L, Parenti C, Alterio V, et al.
Eur J Med Chem . 2023 Sep; 260:115783. PMID: 37678143
In this study, we investigated the development of dual-targeted ligands that bind to both μ-opioid receptor (MOR) and carbonic anhydrase (CA) enzymes, using fentanyl structure as a template. We synthesized...
10.
De Luca V, Bozzetto L, Giglio C, Tramontano G, De Simone G, Luciano A, et al.
Front Public Health . 2023 Sep; 11:1219661. PMID: 37663860
Background: Self-management of Type 2 diabetes mellitus (T2D) is challenging. Regular self-monitoring of blood glucose and healthy lifestyles are required to improve glycometabolic control, thus delaying diabetes complications, and reducing...