Jonathan C Cohen
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Explore the profile of Jonathan C Cohen including associated specialties, affiliations and a list of published articles.
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115
Citations
16189
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Recent Articles
1.
Wang Y, Hong S, Hudson H, Kory N, Kinch L, Kozlitina J, et al.
J Hepatol
. 2024 Nov;
PMID: 39550037
Background & Aims: PNPLA3(148M) (patatin-like phospholipase domain-containing protein 3) is the most impactful genetic risk factor for steatotic liver disease (SLD). A key unresolved issue is whether PNPLA3(148M) confers a...
2.
Das A, Cheng H, Wang Y, Kinch L, Liang G, Hong S, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2312291121.
PMID: 38294943
A missense variant in patatin-like phospholipase domain-containing protein 3 [PNPLA3(I148M)] is the most impactful genetic risk factor for fatty liver disease (FLD). We previously showed that PNPLA3 is ubiquitylated and...
3.
Hobbs H, Cohen J, Horton J
Circulation
. 2024 Jan;
149(3):171-173.
PMID: 38227713
No abstract available.
4.
Kozlitina J, Cohen N, Sturtevant D, Cohen J, Murphey-Half C, Saltarrelli J, et al.
EClinicalMedicine
. 2024 Jan;
67:102350.
PMID: 38169797
Background: Several genetic variants are associated with chronic liver disease. The role of these variants in outcomes after liver transplantation (LT) is uncertain. The aim of this study was to...
5.
Kubiliun M, Cohen J, Hobbs H, Kozlitina J
Liver Int
. 2022 May;
42(10):2227-2236.
PMID: 35620859
Background And Aims: Susceptibility to fatty liver disease (FLD) varies among individuals and between racial/ethnic groups. Several genetic variants influence FLD risk, but whether these variants explain racial/ethnic differences in...
6.
Luo F, Smagris E, Martin S, Vale G, McDonald J, Fletcher J, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Dec;
13(3):879-899.
PMID: 34923175
Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels....
7.
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34404721
The ABCG1 homodimer (G1) and ABCG5-ABCG8 heterodimer (G5G8), two members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter G family, are required for maintenance of cellular cholesterol levels. G5G8 mediates...
8.
Luo F, Xing C, Asrani S, Li S, Liang G, Hobbs H, et al.
Mol Metab
. 2021 Jul;
53:101299.
PMID: 34271222
A missense variant in the cytoplasmic domain of the insulin receptor (INSR) was identified by exome sequencing in affected members of a four-generation family with fatty liver disease (FLD). The...
9.
Oldoni F, Bass K, Kozlitina J, Hudson H, Shihanian L, Gusarova V, et al.
J Clin Endocrinol Metab
. 2021 Feb;
106(6):1649-1667.
PMID: 33619548
Context: ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but...
10.
Oldoni F, Cheng H, Banfi S, Gusarova V, Cohen J, Hobbs H
JCI Insight
. 2020 Jul;
5(17).
PMID: 32730227
The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that...