Robert E Hammer
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Explore the profile of Robert E Hammer including associated specialties, affiliations and a list of published articles.
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105
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9843
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Recent Articles
1.
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, et al.
Elife
. 2024 Oct;
13.
PMID: 39404750
No abstract available.
2.
Yang J, Butti R, Cohn S, Toffessi-Tcheuyap V, Mal A, Nguyen M, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(25):e2310793121.
PMID: 38861592
mTORC1 is aberrantly activated in renal cell carcinoma (RCC) and is targeted by rapalogs. As for other targeted therapies, rapalogs clinical utility is limited by the development of resistance. Resistance...
3.
Jones B, Han J, Zhang H, Hammer R, Evers B, Rakheja D, et al.
Genes Dev
. 2023 Aug;
37(13-14):661-674.
PMID: 37553261
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets...
4.
Jones B, Han J, Zhang H, Hammer R, Evers B, Rakheja D, et al.
bioRxiv
. 2023 Jul;
PMID: 37425885
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play critical roles in development and disease. Target-directed miRNA degradation (TDMD), a pathway in which miRNAs that bind to specialized targets...
5.
Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, et al.
Cell Metab
. 2023 Mar;
35(3):429-437.e5.
PMID: 36889282
Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. In this report, we show that the hormone FGF21, which...
6.
Garcia J, Chen R, Xu M, Comerford S, Hammer R, Melton S, et al.
PLoS One
. 2023 Mar;
18(3):e0282223.
PMID: 36862715
The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin...
7.
Comerford S, Hinnant E, Chen Y, Hammer R
PLoS Genet
. 2023 Jan;
19(1):e1010595.
PMID: 36656901
Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as the ribosomopathies, core manifestations of which include cytopenias and developmental abnormalities that are believed to...
8.
Pohlkamp T, Xian X, Wong C, Durakoglugil M, Werthmann G, Saido T, et al.
Elife
. 2021 Oct;
10.
PMID: 34617884
Apolipoprotein E4 (ApoE4) is the most important and prevalent risk factor for late-onset Alzheimer's disease (AD). The isoelectric point of ApoE4 matches the pH of the early endosome (EE), causing...
9.
Nagati J, Kobeissy P, Nguyen M, Xu M, Garcia T, Comerford S, et al.
J Biol Chem
. 2021 Aug;
297(3):101037.
PMID: 34343565
Besides contributing to anabolism, cellular metabolites serve as substrates or cofactors for enzymes and may also have signaling functions. Given these roles, multiple control mechanisms likely ensure fidelity of metabolite-generating...
10.
Rios J, Denton K, Russell J, Kozlitina J, Ferreira C, Lewanda A, et al.
J Bone Miner Res
. 2021 Apr;
36(8):1548-1565.
PMID: 33905568
Proper embryonic and postnatal skeletal development require coordination of myriad complex molecular mechanisms. Disruption of these processes, through genetic mutation, contributes to variation in skeletal development. We developed a high-throughput...