Janusz Stepinski
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Explore the profile of Janusz Stepinski including associated specialties, affiliations and a list of published articles.
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62
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1287
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Recent Articles
11.
Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis R, et al.
Biochemistry
. 2012 Sep;
51(40):8003-13.
PMID: 22985415
Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for...
12.
Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, et al.
Nucleic Acids Res
. 2011 Oct;
39(20):8820-32.
PMID: 21965542
Metazoan spliced leader (SL) trans-splicing generates mRNAs with an m(2,2,7)G-cap and a common downstream SL RNA sequence. The mechanism for eIF4E binding an m²²⁷G-cap is unknown. Here, we describe the...
13.
Kiraga-Motoszko K, Niedzwiecka A, Modrak-Wojcik A, Stepinski J, Darzynkiewicz E, Stolarski R
J Phys Chem B
. 2011 Jun;
115(27):8746-54.
PMID: 21650456
Molecular mechanisms underlying the recognition of the mRNA 5' terminal structure called "cap" by the eukaryotic initiation factor 4E (eIF4E) are crucial for cap-dependent translation. To gain a deeper insight...
14.
Frank F, Fabian M, Stepinski J, Jemielity J, Darzynkiewicz E, Sonenberg N, et al.
EMBO Rep
. 2011 Apr;
12(5):415-20.
PMID: 21475248
In RNA silencing, microRNA (miRNA)-mediated translational repression occurs through mechanisms that do not invoke messenger-RNA (mRNA) target cleavage by Argonaute proteins. The nature of these mechanisms is unclear, but several...
15.
Guranowski A, Wojdyla A, Rydzik A, Stepinski J, Jemielity J
Acta Biochim Pol
. 2011 Mar;
58(1):131-6.
PMID: 21403921
Adenosine 5'-phosphoramidate (NH₂-pA) is an uncommon natural nucleotide of poorly understood biochemistry and function. We studied a plant enzyme potentially involved in the catabolism of NH₂-pA. A fast and simple...
16.
Belanger F, Stepinski J, Darzynkiewicz E, Pelletier J
J Biol Chem
. 2010 Aug;
285(43):33037-33044.
PMID: 20713356
Cellular eukaryotic mRNAs are capped at their 5' ends with a 7-methylguanosine nucleotide, a structural feature that has been shown to be important for conferring mRNA stability, stimulating mRNA biogenesis...
17.
Wypijewska A, Bojarska E, Stepinski J, Jankowska-Anyszka M, Jemielity J, Davis R, et al.
FEBS J
. 2010 Jun;
277(14):3003-13.
PMID: 20546305
The activity of the Caenorhabditis elegans scavenger decapping enzyme (DcpS) on its natural substrates and dinucleotide cap analogs, modified with regard to the nucleoside base or ribose moiety, has been...
18.
Wallace A, Filbin M, Veo B, McFarland C, Stepinski J, Jankowska-Anyszka M, et al.
Mol Cell Biol
. 2010 Feb;
30(8):1958-70.
PMID: 20154140
Eukaryotic mRNA translation begins with recruitment of the 40S ribosome complex to the mRNA 5' end through the eIF4F initiation complex binding to the 5' m(7)G-mRNA cap. Spliced leader (SL)...
19.
Benarroch D, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Shuman S
RNA
. 2009 Nov;
16(1):211-20.
PMID: 19926722
The Tgs proteins are structurally homologous AdoMet-dependent eukaryal enzymes that methylate the N2 atom of 7-methyl guanosine nucleotides. They have an imputed role in the synthesis of the 2,2,7-trimethylguanosine (TMG)...
20.
Liu W, Zhao R, McFarland C, Kieft J, Niedzwiecka A, Jankowska-Anyszka M, et al.
J Biol Chem
. 2009 Aug;
284(45):31336-49.
PMID: 19710013
The eukaryotic translation initiation factor eIF4E recognizes the mRNA cap, a key step in translation initiation. Here we have characterized eIF4E from the human parasite Schistosoma mansoni. Schistosome mRNAs have...