Jan Sjovall
Overview
Explore the profile of Jan Sjovall including associated specialties, affiliations and a list of published articles.
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33
Citations
816
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Recent Articles
1.
Abdel-Khalik J, Hearn T, Dickson A, Crick P, Yutuc E, Austin-Muttitt K, et al.
J Steroid Biochem Mol Biol
. 2020 Nov;
206:105794.
PMID: 33246156
Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine. Here we have...
2.
Theofilopoulos S, Griffiths W, Crick P, Yang S, Meljon A, Ogundare M, et al.
J Clin Invest
. 2014 Oct;
124(11):4829-42.
PMID: 25271621
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated...
3.
Theofilopoulos S, Wang Y, Kitambi S, Sacchetti P, Sousa K, Bodin K, et al.
Nat Chem Biol
. 2013 Jan;
9(2):126-33.
PMID: 23292650
Liver X receptors (Lxrα and Lxrβ) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified. Here we...
4.
Griffiths W, Sjovall J
Biochem Biophys Res Commun
. 2010 May;
396(1):80-4.
PMID: 20494115
Cholesterol is the precursor of many compounds with functions in the physiology and metabolism of the organism. Methods for the multicomponent analysis of these compounds and their metabolites (metabolomics) are...
5.
Griffiths W, Sjovall J
J Lipid Res
. 2009 Dec;
51(1):23-41.
PMID: 20008121
The formation of bile acids/bile alcohols is of major importance for the maintenance of cholesterol homeostasis. Besides their functions in lipid absorption, bile acids/bile alcohols are regulatory molecules for a...
6.
Ogundare M, Theofilopoulos S, Lockhart A, Hall L, Arenas E, Sjovall J, et al.
J Biol Chem
. 2009 Dec;
285(7):4666-79.
PMID: 19996111
In this study we have profiled the free sterol content of cerebrospinal fluid by a combination of charge tagging and liquid chromatography-tandem mass spectrometry. Surprisingly, the most abundant cholesterol metabolites...
7.
Liere P, Pianos A, Eychenne B, Cambourg A, Bodin K, Griffiths W, et al.
J Lipid Res
. 2009 Jun;
50(12):2430-44.
PMID: 19506304
Pregnenolone (PREG) and dehydroepiandrosterone (DHEA), and their respective sulfated forms PREGS and DHEAS, were among the first steroids to be identified in rodent brain. However, unreliable steroid isolation and solvolysis...
8.
Wang Y, Sousa K, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, et al.
Mol Biosyst
. 2009 Apr;
5(5):529-41.
PMID: 19381367
In this study two regions of embryonic (E11) mouse central nervous system (CNS) have been profiled for their unesterified sterol content. Using high-performance liquid chromatography (HPLC)-mass spectrometry (MS) and tandem...
9.
Termen S, Tollin M, Rodriguez E, Sveinsdottir S, Johannesson B, Cederlund A, et al.
Mol Immunol
. 2008 Jul;
45(15):3947-55.
PMID: 18657865
Mammalian antimicrobial peptides contribute to the protective barrier against microbes at epithelial surfaces. This study focuses on the promoter of the human CAMP gene, encoding the antimicrobial peptide LL-37, and...
10.
Griffiths W, Hornshaw M, Woffendin G, Baker S, Lockhart A, Heidelberger S, et al.
J Proteome Res
. 2008 Jul;
7(8):3602-12.
PMID: 18605750
While the proteome defines the expressed gene products, the metabolome results from reactions controlled by such gene products. Plasma represents an accessible "window" to the metabolome both in regard of...