Johan Lengqvist
Overview
Explore the profile of Johan Lengqvist including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
722
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Recent Articles
1.
Preger C, Wigren E, Ossipova E, Marks C, Lengqvist J, Hofstrom C, et al.
J Biol Chem
. 2020 Aug;
295(41):13981-13993.
PMID: 32817337
Aminoacyl-tRNA synthetases (aaRSs) have long been viewed as mere housekeeping proteins and have therefore often been overlooked in drug discovery. However, recent findings have revealed that many aaRSs have noncanonical...
2.
Steinmetz J, Senkowski W, Lengqvist J, Rubin J, Ossipova E, Herman S, et al.
ACS Omega
. 2020 Jul;
5(28):17242-17254.
PMID: 32715210
We have previously identified selective upregulation of the mevalonate pathway genes upon inhibition of oxidative phosphorylation (OXPHOS) in quiescent cancer cells. Using mass spectrometry-based proteomics, we here investigated whether these...
3.
Emmerich A, Wellstein J, Ossipova E, Baumann I, Lengqvist J, Kultima K, et al.
Front Pharmacol
. 2020 Apr;
11:196.
PMID: 32231562
MicroRNAs (miRs) are one of the most important post-transcriptional repressors of gene expression. However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a...
4.
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas D, Urbina C, Nandakumar K, et al.
J Exp Med
. 2019 Jun;
216(8):1904-1924.
PMID: 31196979
Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage...
5.
Estelius J, Lengqvist J, Ossipova E, Idborg H, Le Maitre E, Andersson M, et al.
Arthritis Res Ther
. 2019 Feb;
21(1):60.
PMID: 30770760
Background: Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade....
6.
Lim Y, Prabhu N, Dai L, Go K, Chen D, Sreekumar L, et al.
PLoS One
. 2018 Dec;
13(12):e0208273.
PMID: 30521565
Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such...
7.
Emami Khoonsari P, Ossipova E, Lengqvist J, Svensson C, Kosek E, Kadetoff D, et al.
J Proteomics
. 2018 Jun;
190:67-76.
PMID: 29852297
Chronic pain represents one of the major medical challenges in the 21st century, affecting >1.5 billion of the world population. Overlapping and heterogenous symptoms of various chronic pain conditions complicate...
8.
Tan C, Go K, Bisteau X, Dai L, Yong C, Prabhu N, et al.
Science
. 2018 Feb;
359(6380):1170-1177.
PMID: 29439025
Proteins differentially interact with each other across cellular states and conditions, but an efficient proteome-wide strategy to monitor them is lacking. We report the application of thermal proximity coaggregation (TPCA)...
9.
Persson H, Preger C, Marcon E, Lengqvist J, Graslund S
Methods Mol Biol
. 2017 Mar;
1575:175-187.
PMID: 28255880
We describe a mass spectrometry-based approach for validation of antibody specificity. This method allows validation of antibodies or antibody fragments, against their endogenous targets. It can assess if the antibody...
10.
Senkowski W, Jarvius M, Rubin J, Lengqvist J, Gustafsson M, Nygren P, et al.
Cell Chem Biol
. 2016 Dec;
23(11):1428-1438.
PMID: 27984028
Cancer cell lines grown as two-dimensional (2D) cultures have been an essential model for studying cancer biology and anticancer drug discovery. However, 2D cancer cell cultures have major limitations, as...