Jan Sjovall
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Explore the profile of Jan Sjovall including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
816
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Recent Articles
11.
Wang Y, Muneton S, Sjovall J, Jovanovic J, Griffiths W
J Proteome Res
. 2008 Feb;
7(4):1606-14.
PMID: 18303831
In humans, the brain represents only about 2% of the body's mass but contains about one-quarter of the body's free cholesterol. Cholesterol is synthesized de novo in brain and removed...
12.
Schumacher M, Liere P, Akwa Y, Rajkowski K, Griffiths W, Bodin K, et al.
Neurochem Int
. 2007 Dec;
52(4-5):522-40.
PMID: 18068870
Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic and by stimulating glutamatergic neurotransmission. PREGS is also a...
13.
Nilsson L, Sjovall J, Strom S, Bodin K, Nowak G, Einarsson C, et al.
Biochem Biophys Res Commun
. 2007 Nov;
364(4):743-7.
PMID: 17976534
The conversion of cholesterol to bile acids is a key pathway for elimination of cholesterol from the body, thereby reducing the risk of arteriosclerosis. Moderate consumption of ethanol has been...
14.
Karu K, Hornshaw M, Woffendin G, Bodin K, Hamberg M, Alvelius G, et al.
J Lipid Res
. 2007 Jan;
48(4):976-87.
PMID: 17251593
In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomes...
15.
Jokinen M, Neuvonen P, Lindgren L, Hockerstedt K, Sjovall J, Breuer O, et al.
Anesthesiology
. 2007 Jan;
106(1):43-55.
PMID: 17197844
Background: Ropivacaine is mainly eliminated by hepatic metabolism. The authors studied the effect of chronic end-stage liver disease on the pharmacokinetics of ropivacaine. Methods: Thirteen patients with chronic end-stage liver...
16.
Griffiths W, Wang Y, Alvelius G, Liu S, Bodin K, Sjovall J
J Am Soc Mass Spectrom
. 2006 Jan;
17(3):341-62.
PMID: 16442307
Oxysterols are oxygenated derivatives of cholesterol. They are intermediates in cholesterol excretion pathways and may also be regarded as transport forms of cholesterol. The introduction of additional hydroxyl groups to...
17.
Wang Y, Hornshaw M, Alvelius G, Bodin K, Liu S, Sjovall J, et al.
Anal Chem
. 2005 Dec;
78(1):164-73.
PMID: 16383324
Neutral steroids have traditionally been analyzed by gas chromatography/mass spectrometry (GC/MS) after necessary derivatization reactions. However, GC/MS is unsuitable for the analysis of many conjugated steroids and those with unsuspected...
18.
Marschall H, Wagner M, Bodin K, Zollner G, Fickert P, Gumhold J, et al.
J Lipid Res
. 2005 Dec;
47(3):582-92.
PMID: 16327028
Farnesoid X receptor knockout (Fxr(-/-)) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions. To investigate whether Fxr(-/-) mice differ in bile acid detoxification...
19.
Lengqvist J, Mata de Urquiza A, Perlmann T, Sjovall J, Griffiths W
J Mass Spectrom
. 2005 Nov;
40(11):1448-61.
PMID: 16258897
Electrospray (ES) mass spectrometry data is presented showing that agonist binding to the nuclear receptor (NR), retinoid X receptor alpha (RXRalpha), is competitive. The competitive nature of agonist binding can...
20.
Khan M, Wang Y, Heidelberger S, Alvelius G, Liu S, Sjovall J, et al.
Steroids
. 2005 Oct;
71(1):42-53.
PMID: 16199070
Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P...