Jacob Andersen
Overview
Explore the profile of Jacob Andersen including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
886
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0
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Recent Articles
1.
Jorgensen M, Paulsen F, Bentien A, Kjul A, Poulsen M, Mikkelsen L, et al.
Sci Rep
. 2023 Sep;
13(1):15237.
PMID: 37709852
Membrane fouling significantly reduces membrane permeability, leading to higher operational expenses. In situ monitoring of membrane fouling can potentially be used to reduce operation cost by optimizing operational parameters and...
2.
Braun N, Friis S, Ihling C, Sinz A, Andersen J, Pless S
PLoS Biol
. 2021 Sep;
19(9):e3001321.
PMID: 34491979
Incorporation of noncanonical amino acids (ncAAs) can endow proteins with novel functionalities, such as crosslinking or fluorescence. In ion channels, the function of these variants can be studied with great...
3.
Petersen L, Christensen A, Andersen J, Folkesson C, Kristensen O, Andersen C, et al.
J Am Chem Soc
. 2021 Feb;
143(7):2751-2756.
PMID: 33577316
DNA-encoded small molecule libraries (DELs) have facilitated the discovery of novel modulators of many different therapeutic protein targets. We report the first successful screening of a multimillion membered DEL inside...
4.
Borg C, Braun N, Heusser S, Bay Y, Weis D, Galleano I, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(13):7447-7454.
PMID: 32165542
Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great...
5.
Rannversson H, Andersen J, Bang-Andersen B, Stromgaard K
ACS Chem Biol
. 2017 Sep;
12(10):2558-2562.
PMID: 28910072
In spite of the important role of the human serotonin transporter (hSERT) in depression treatment, the molecular details of how antidepressant drugs bind are still not completely understood, in particular...
6.
Andersen J, Ladefoged L, Kristensen T, Munro L, Grouleff J, Stuhr-Hansen N, et al.
ACS Chem Neurosci
. 2016 Jul;
7(10):1406-1417.
PMID: 27425420
The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Studies...
7.
Rannversson H, Andersen J, Sorensen L, Bang-Andersen B, Park M, Huber T, et al.
Nat Commun
. 2016 Apr;
7:11261.
PMID: 27089947
Despite the well-established role of the human serotonin transporter (hSERT) in the treatment of depression, the molecular details of antidepressant drug binding are still not fully understood. Here we utilize...
8.
Larsen M, Plenge P, Andersen J, Eildal J, Kristensen A, Bogeso K, et al.
Br J Pharmacol
. 2015 Dec;
173(5):925-36.
PMID: 26699847
Background And Purpose: The 5-HT transporter (SERT) is a target for antidepressant drugs. SERT possesses two binding sites: the orthosteric (S1) binding site, which is the presumed target for current...
9.
Andersen J, Ringsted K, Bang-Andersen B, Stromgaard K, Kristensen A
Sci Rep
. 2015 Oct;
5:15650.
PMID: 26503701
The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Despite a strikingly similar...
10.
Andersen J, Ladefoged L, Wang D, Kristensen T, Bang-Andersen B, Kristensen A, et al.
ACS Chem Neurosci
. 2015 Sep;
6(11):1892-900.
PMID: 26389667
Selective inhibitors of the human serotonin transporter (hSERT) have been first-line treatment against depression for several decades. Recently, vortioxetine was approved as a new therapeutic option for the treatment of...