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Jacob Andersen

Explore the profile of Jacob Andersen including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 886
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Recent Articles
11.
Soderhielm P, Andersen J, Munro L, Nielsen A, Kristensen A
Mol Pharmacol . 2015 Jul; 88(4):676-88. PMID: 26174773
The serotonin transporter (SERT) regulates neurotransmission by the biogenic monoamine neurotransmitter serotonin (5-HT, 5-hydroxytryptamine) in the central nervous system, and drugs inhibiting SERT are widely used for the treatment of...
12.
Rannversson H, Wilson P, Kristensen K, Sinning S, Kristensen A, Stromgaard K, et al.
J Biol Chem . 2015 Apr; 290(23):14582-94. PMID: 25903124
The serotonin transporter (SERT) terminates serotonergic neurotransmission by performing reuptake of released serotonin, and SERT is the primary target for antidepressants. SERT mediates the reuptake of serotonin through an alternating...
13.
Poulsen M, Andersen J, Christensen R, Hansen K, Traynelis S, Stromgaard K, et al.
J Mol Biol . 2014 May; 427(1):176-89. PMID: 24862283
The N-methyl-d-aspartate receptors (NMDARs) constitute an important class of ligand-gated cation channels that are involved in the majority of excitatory neurotransmission in the human brain. Compounds that bind in the...
14.
Andersen J, Stuhr-Hansen N, Zachariassen L, Koldso H, Schiott B, Stromgaard K, et al.
Mol Pharmacol . 2014 Feb; 85(5):703-14. PMID: 24516100
Inhibitors of the serotonin transporter (SERT) are widely used antidepressant agents, but the structural mechanism for inhibitory activity and selectivity over the closely related norepinephrine transporter (NET) is not well...
15.
Crestey F, Jensen A, Borch M, Andreasen J, Andersen J, Balle T, et al.
J Med Chem . 2013 Nov; 56(23):9673-82. PMID: 24187998
The synthesis of a new series of Erythrina alkaloid analogues and their pharmacological characterization at various nicotine acetylcholine receptor (nAChR) subtypes are described. The compounds were designed to be simplified...
16.
Norager N, Jensen C, Rathje M, Andersen J, Madsen K, Kristensen A, et al.
ACS Chem Biol . 2013 Jul; 8(9):2033-41. PMID: 23838571
The natural product argiotoxin-636 (ArgTX-636) found in the venom of the Argiope lobata spider is a potent open-channel blocker of ionotropic glutamate (iGlu) receptors, and recently, two analogues, ArgTX-75 and...
17.
Jager A, Gauguin B, Andersen J, Adsersen A, Gudiksen L
J Ethnopharmacol . 2012 Dec; 145(3):822-5. PMID: 23266274
Ethnopharmacological Relevance: A number of plant species are used in Danish folk medicine for treatment of depression and anxiety. Materials And Methods: Aqueous and ethanolic extracts of 17 plant species...
18.
Sorensen L, Andersen J, Thomsen M, Hansen S, Zhao X, Sandelin A, et al.
J Biol Chem . 2012 Oct; 287(52):43694-707. PMID: 23086945
The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. A wide...
19.
Fog-Moller T, Andersen J
Ugeskr Laeger . 2012 Apr; 174(16):1096-7. PMID: 22510553
Lactococcus garvieae are Gram-positive, facultative anaerobe cocci. The bacterium is a known pathogen in fish, but is also described in mastitis among ruminants. In recent years it has been found...
20.
Kristensen A, Andersen J, Jorgensen T, Sorensen L, Eriksen J, Loland C, et al.
Pharmacol Rev . 2011 Jul; 63(3):585-640. PMID: 21752877
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene family (also referred to as the neurotransmitter-sodium-symporter family or Na(+)/Cl(-)-dependent transporters) comprise a group of nine sodium- and...